# A Case Report of a Syndromic Triad of Persistent Urogenital Sinus, Herlyn–Werner–Wunderlich Syndrome, and Prune Belly Syndrome in a Neonate

## TL;DR

A premature baby girl was born with a rare combination of three urogenital and abdominal wall abnormalities requiring complex medical care.

## Contribution

The paper reports a rare syndromic triad of urogenital anomalies in a neonate, highlighting diagnostic and therapeutic challenges.

## Key findings

- The neonate exhibited persistent urogenital sinus, Herlyn–Werner–Wunderlich syndrome, and Prune Belly-like syndrome.
- Management involved staged urinary drainage, septum incision, and multidisciplinary care to improve outcomes.
- Early recognition and individualized care are critical for managing such complex congenital anomalies.

## Abstract

We present a case of a premature female neonate with a triad of persistent urogenital sinus with urinary ascites, bilateral hydrocolpos in a duplex uterus, and abdominal wall hypoplasia resembling Prune Belly-like syndrome, combined with severe bilateral cystic dysplastic kidneys and complex urinary obstruction.

A female infant was born at 34
3/7
weeks' gestation via cesarean section due to prenatal detection of hydrops fetalis and massive urinary ascites. Prenatal ultrasound had shown oligohydramnios, ascites, megacystis, and hydrocolpos. Postnatally, urinary ascites, a persistent urogenital sinus, severe upper urinary tract dilation, bilateral dysplastic kidneys, and an obstructive vaginal septum were confirmed. Management included staged urinary drainage, vaginal septum incision, intensive respiratory and renal support, and multidisciplinary care.

This unique combination of anomalies presents significant diagnostic and therapeutic challenges. Early recognition and individualized multidisciplinary management are essential to improve postnatal outcomes and guide long-term planning in such cases.