# Advancing global health access through market shaping: Cases and learnings

**Authors:** Claire M. Wagner, Amy Lin, Sabin Nsanzimana, Janet K. Ginnard, Jayasree K. Iyer, Mary-Ann Etiebet, David Ripin, Sandeep Juneja, Dominic Hein, Gian Gandhi, Charles B. Holmes

PMC · DOI: 10.1371/journal.pgph.0004523 · PLOS Global Public Health · 2026-02-24

## TL;DR

This paper explores how market shaping strategies can help get effective health products to low- and middle-income countries faster.

## Contribution

It provides practical insights and lessons from real-world cases of market shaping in global health.

## Key findings

- Market shaping tools can influence prices, supply, and demand for health products in LMICs.
- Case studies highlight successes and challenges in implementing these strategies.
- The paper identifies research priorities to improve the use of market shaping in global health.

## Abstract

New health products have contributed to major improvements in public health, but many clinically effective interventions still face delays in reaching low- and middle-income countries (LMICs). Market shaping approaches have emerged as a set of tools designed to address such access gaps by influencing prices, supply, and demand. Drawing on practitioner experience and illustrative cases, this paper examines how market shaping mechanisms have been used to expand access to pharmaceutical products in LMICs. We review examples including dolutegravir, rifapentine-based tuberculosis preventive therapy, pretomanid for drug-resistant tuberculosis, the RTS,S malaria vaccine, and Rwanda’s hepatitis C program, alongside ecosystem-level interventions such as revolving funds and initiatives to strengthen regional manufacturing. Across these cases, we suggest generalizable lessons and describe trade-offs related to donor dependence, supplier concentration, and timing of interventions. The paper identifies priorities for empirical research to assess the performance, risks, and applicability of market shaping tools as global health needs and resource environments evolve.

## Linked entities

- **Diseases:** tuberculosis (MONDO:0018076), malaria (MONDO:0005136)

## Full-text entities

- **Diseases:** DR-TB (MESH:D018088), hepatitis C (MESH:D019698), infection (MESH:D007239), COVID (MESH:D000086382), TB (MESH:D014376), drug (MESH:D000081015), AIDS (MESH:D000163), infectious diseases (MESH:D003141), HIV (MESH:D015658), Malaria (MESH:D008288)
- **Chemicals:** pretomanid (MESH:C410767), rifapentine (MESH:C018421), Sofosbuvir-Ledipasvir (MESH:C000595958), isoniazid (MESH:D007538), 1HP (-), DTG (MESH:C562325), Sofosbuvir (MESH:D000069474), Ledipasvir (MESH:C586541), artemisinin (MESH:C031327)
- **Species:** Ebola virus (no rank) [taxon 1570291], hepatitis C virus [taxon 11103], Plasmodium falciparum (malaria parasite P. falciparum, species) [taxon 5833], Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12931745/full.md

## References

95 references — full list in the complete paper: https://tomesphere.com/paper/PMC12931745/full.md

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Source: https://tomesphere.com/paper/PMC12931745