# A Case of Pulmonary Thromboembolism in a Child With Steroid-Resistant Nephrotic Syndrome

**Authors:** C. Annette Reyes, Ei Khin

PMC · DOI: 10.7759/cureus.102260 · Cureus · 2026-01-25

## TL;DR

A child with a kidney disease had a dangerous blood clot in her lungs, showing the need for careful monitoring and quick treatment.

## Contribution

This case emphasizes the risk of blood clots in children with steroid-resistant nephrotic syndrome and the importance of timely diagnosis and treatment.

## Key findings

- A child with steroid-resistant nephrotic syndrome developed a life-threatening pulmonary thromboembolism.
- Prompt anticoagulation treatment with heparin and enoxaparin was initiated following diagnosis.
- The case highlights the hypercoagulable state in SRNS and the need for vigilance in managing complications.

## Abstract

A seven-year-old girl with steroid-resistant nephrotic syndrome (SRNS) presented to the Emergency Department with chest pain, palpitations, dyspnea, and generalized edema. She had been receiving immunosuppressants but remained nephrotic. During evaluation, she was found to have an acute occlusive pulmonary thromboembolism (PTE), confirmed by CT pulmonary angiography. Anticoagulation was initiated promptly with heparin, followed by enoxaparin, a low-molecular-weight, long-acting heparin.

This case highlights the increased risk of thromboembolic events in children with SRNS due to their hypercoagulable state. It underscores the importance of vigilant SRNS management, awareness of life-threatening complications, such as pulmonary embolism (PE), timely imaging, and prompt treatment.

## Linked entities

- **Diseases:** steroid-resistant nephrotic syndrome (MONDO:0044765)

## Full-text entities

- **Genes:** VWF (von Willebrand factor) [NCBI Gene 7450] {aka F8VWF, VWD}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}, PROC (protein C, inactivator of coagulation factors Va and VIIIa) [NCBI Gene 5624] {aka APC, PC, PROC1, THPH3, THPH4}, F5 (coagulation factor V) [NCBI Gene 2153] {aka FVL, PCCF, RPRGL1, THPH2, fV}, F2 (coagulation factor II, thrombin) [NCBI Gene 2147] {aka PT, RPRGL2, THPH1}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, NPHS2 (NPHS2 stomatin family member, podocin) [NCBI Gene 7827] {aka PDCN, SRN1}, SERPINC1 (serpin family C member 1) [NCBI Gene 462] {aka AT3, AT3D, ATIII, ATIII-R2, ATIII-T1, ATIII-T2}
- **Diseases:** hyperlipidemia (MESH:D006949), FSGS (MESH:D005923), tachycardia (MESH:D013610), Kidney Disease (MESH:D007674), syncope (MESH:D013575), thrombosis (MESH:D013927), bleeding (MESH:D006470), rash (MESH:D005076), atrial septal defect (MESH:D006344), Circulatory failure (MESH:D012769), bruising (MESH:D003288), ascites (MESH:D001201), headache (MESH:D006261), prematurity (MESH:C536271), tenderness (MESH:D063806), congenital nephrotic syndrome, type 2 (MESH:C535761), hypoalbuminemia (MESH:D034141), NS (MESH:D009404), palpitations (MESH:D006331), influenza (MESH:D007251), chest pain (MESH:D002637), TE (MESH:D013923), hypertension (MESH:D006973), occlusive (MESH:D001157), VTE (MESH:D054556), aortic insufficiency (MESH:D001022), volume depletion (MESH:C536350), fever (MESH:D005334), COVID-19 (MESH:D000086382), patent foramen ovale (MESH:D054092), proteinuria (MESH:D011507), lupus nephritis (MESH:D008181), PE (MESH:D011655), occlusive pulmonary thromboembolus (MESH:D011668), hypotension (MESH:D007022), right ventricular dysfunction (MESH:D018497), oliguria (MESH:D009846), dyspnea (MESH:D004417), coagulation (MESH:D001778), infection (MESH:D007239), edema (MESH:D004487), chronic renal impairment (MESH:D051436), asthma (MESH:D001249), chest pressure (MESH:D013898), tachypnea (MESH:D059246), dehydration (MESH:D003681), DVT (MESH:D020246), joint pain (MESH:D018771), cough (MESH:D003371), mitral regurgitation (MESH:D008944), abdominal pain (MESH:D015746), ASD (MESH:D001321)
- **Chemicals:** methylprednisolone (MESH:D008775), prednisolone (MESH:D011239), Steroid (MESH:D013256), prednisone (MESH:D011241), Anti-Xa (-), lisinopril (MESH:D017706), oxygen (MESH:D010100), tacrolimus (MESH:D016559), famotidine (MESH:D015738), albuterol (MESH:D000420), UFH (MESH:D006493), rituximab (MESH:D000069283), vitamin K (MESH:D014812), furosemide (MESH:D005665), enoxaparin (MESH:D017984), creatinine (MESH:D003404), LMWH (MESH:D006495)
- **Species:** Streptococcus pneumoniae (species) [taxon 1313], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** p.Leu330Valfs*15, c.988_989del

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12931568/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12931568/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12931568/full.md

---
Source: https://tomesphere.com/paper/PMC12931568