# Beyond the Skin: Granulomatous Uveitis Linked to Active Tattoo Inflammation

**Authors:** Poliana de Jesus Araujo, Marlos Henrique Sousa de Oliveira Junior, Rodrigo A Torres, Ricardo Danilo C Oliveira, Paulo C Fontana

PMC · DOI: 10.7759/cureus.102255 · Cureus · 2026-01-25

## TL;DR

A young woman with active tattoo inflammation developed eye inflammation, showing a rare link between tattoos and uveitis.

## Contribution

This case report identifies granulomatous uveitis as a rare consequence of tattoo inflammation.

## Key findings

- A patient with longstanding black-ink tattoos developed bilateral visual symptoms and skin inflammation.
- Skin biopsy confirmed granulomatous inflammation with exogenous pigment.
- The patient improved with corticosteroid treatment, suggesting a causal link between tattoo inflammation and uveitis.

## Abstract

Tattoo-associated granulomatous uveitis is an uncommon inflammatory reaction in which ocular findings accompany immune responses at tattoo sites. We report a young woman who presented with bilateral visual symptoms along with redness and scaling over longstanding black-ink tattoos. Infectious and systemic causes were excluded through comprehensive evaluation, and skin biopsy confirmed granulomatous inflammation with exogenous pigment. The patient improved with systemic and topical corticosteroids. This case highlights the importance of recognizing tattoo-related inflammatory responses as a potential cause of uveitis when no clear etiology is identified.

## Full-text entities

- **Genes:** ACE (angiotensin I converting enzyme) [NCBI Gene 1636] {aka ACE1, CD143, DCP, DCP1}, LYZ (lysozyme) [NCBI Gene 4069] {aka AMYLD5, LYZF1, LZM}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** posterior synechiae (MESH:D006175), systemic disease (MESH:D034721), toxocariasis (MESH:D014120), anterior uveitis (MESH:D014606), Granulomatous Uveitis (MESH:D014605), hyperemia (MESH:D006940), ocular and cutaneous immune-mediated disease (MESH:C567355), desquamation (MESH:D017490), vitreous opacity (MESH:D003318), pulmonary or lymphatic disease (MESH:D008206), cytomegalovirus (MESH:D003586), cutaneous lesions (MESH:D009059), edema (MESH:D004487), blurred vision (MESH:D014786), granulomatous (MESH:D013968), Inflammation (MESH:D007249), vasculitis (MESH:D014657), papilledema (MESH:D010211), syphilis (MESH:D013587), herpes (MESH:C536395), choroiditis (MESH:D002833), infectious and systemic granulomatous diseases (MESH:D003141), toxoplasmosis (MESH:D014123), bilateral panuveitis (MESH:D015864), HIV (MESH:D015658), erythema (MESH:D004890), granulomas (MESH:D006099), hypersensitivity (MESH:D004342), tenderness (MESH:D063806), bartonellosis (MESH:D001474), anterior lens opacity (MESH:D002386), rubella (MESH:D012409), TAGU (MESH:C567128), vascular congestion (MESH:D002311), Sarcoidosis (MESH:D012507), retinal (MESH:D012173), photophobia (MESH:D020795)
- **Chemicals:** prednisolone acetate (MESH:C009935), heavy metals (MESH:D019216), eosin (MESH:D004801), prednisone (MESH:D011241), hematoxylin (MESH:D006416), TAGU (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12931476/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12931476/full.md

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Source: https://tomesphere.com/paper/PMC12931476