# Is CLL curable?

**Authors:** Nitin Jain, Alessandra Ferrajoli, Susan O'Brien, William Wierda

PMC · DOI: 10.1002/hem3.70308 · HemaSphere · 2026-02-24

## Full-text entities

- **Genes:** TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, CD19 (CD19 molecule) [NCBI Gene 930] {aka B4, CVID3}, BTK (Bruton tyrosine kinase) [NCBI Gene 695] {aka AGMX1, AT, ATK, BPK, IGHD3, IMD1}, BCL2 (BCL2 apoptosis regulator) [NCBI Gene 596] {aka Bcl-2, PPP1R50}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, IGHV3-69-1 (immunoglobulin heavy variable 3-69-1 (pseudogene)) [NCBI Gene 28402] {aka IGHV3-H, IGHV3H}
- **Diseases:** myelodysplastic syndromes (MESH:D009190), Blood Cancer (MESH:D019337), acute myeloid leukemia (MESH:D015470), B-cell malignancies (MESH:D016393), Cancer (MESH:D009369), CLL (MESH:D015451)
- **Chemicals:** cyclophosphamide (MESH:D003520), ibrutinib (MESH:C551803), acalabrutinib (MESH:C000604908), fludarabine (MESH:C024352), zanubrutinib (MESH:C000629551), rituximab (MESH:D000069283), venetoclax (MESH:C579720), T (MESH:D014316), lisocabtagene maraleucel (-), obinutuzumab (MESH:C543332), pirtobrutinib (MESH:C000723100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

28 references — full list in the complete paper: https://tomesphere.com/paper/PMC12931421/full.md

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Source: https://tomesphere.com/paper/PMC12931421