# Network meta-analysis of different acupuncture methods for post-stroke upper-limb spasticity

**Authors:** Fanyu Xing, Rongwei Zhang, Yang Guo, Yanfei Wang, Yuhong Guo, Linxuan Yang, Zhaoqing Wang, Zhitong Liu, Ruixing Jiang, Jingyi Wang, Yiting Zhao, Jiangwei Shi, Lili Yin

PMC · DOI: 10.3389/fneur.2026.1725618 · Frontiers in Neurology · 2026-02-10

## TL;DR

This study compares different acupuncture methods for treating upper-limb spasticity after stroke and finds some combinations with rehabilitation are more effective.

## Contribution

The study provides a network meta-analysis comparing multiple acupuncture protocols for post-stroke spasticity.

## Key findings

- Balanced Yin-Yang Acupuncture + Rehabilitation improved Fugl–Meyer Assessment scores most effectively.
- Luan’s Three-Needle Technique combined with Meridian Sinew Cluster Needling + Rehabilitation reduced modified Ashworth scale scores best.
- Two acupuncture methods combined with rehabilitation showed superior efficacy in treating post-stroke upper-limb spasticity.

## Abstract

Currently, acupuncture therapy is widely used for post-stroke upper-limb spasticity. However, the available evidence remains insufficient to determine the relative effectiveness of different acupuncture protocols.

This study retrieved relevant databases and systematically reviewed randomized controlled trials (RCTs) on acupuncture treatment for post-stroke upper-limb spasticity. A total of 28 trials involving 14 acupuncture treatment protocols were included. A network meta-analysis was performed using Stata 18 software.

The results indicated that the Balanced Yin-Yang Acupuncture + Rehabilitation yielded the best outcomes in improving Fugl–Meyer Assessment scores, while Luan’s Three-Needle Technique combined with Meridian Sinew Cluster Needling + Rehabilitation was most effective in reducing modified Ashworth scale scores.

A comparison of efficacy indicators across 14 different acupuncture methods combined with rehabilitation showed that Balanced Yin-Yang Acupuncture + Rehabilitation and Luan’s Three-Needle Technique combined with Meridian Sinew Cluster Needling + Rehabilitation were more effective in treating post-stroke upper-limb spasticity. Owing to limitations in the current body of research, these conclusions need to be further verified by more high-quality randomized controlled trials.

https://www.crd.york.ac.uk/PROSPERO, identifier CRD420251110982.

## Full-text entities

- **Genes:** TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, ENO2 (enolase 2) [NCBI Gene 2026] {aka HEL-S-279, NSE}
- **Diseases:** cerebral infarction (MESH:D002544), -limb spasticity (MESH:D009128), FMA (MESH:C536620), spasm (MESH:D013035), cerebral hemorrhage (MESH:D002543), MAS (MESH:C538175), spastic paralysis (MESH:C538358), upper-limb spasticity (MESH:D038062), motor disorder (MESH:D000068079), limb flexor spasticity (MESH:D052582), -stroke (MESH:D020521), fatigue (MESH:D005221)
- **Chemicals:** SUCRA (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12931285/full.md

## References

39 references — full list in the complete paper: https://tomesphere.com/paper/PMC12931285/full.md

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Source: https://tomesphere.com/paper/PMC12931285