# Peer review of the pesticide risk assessment of the active substance ziram

**Authors:** Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza

PMC · DOI: 10.2903/j.efsa.2026.9869 · EFSA Journal · 2026-02-24

## TL;DR

This paper summarizes the peer review of ziram, a fungicide, assessing its safety and residue levels on fruit trees in the EU.

## Contribution

The paper provides updated conclusions on ziram's risk assessment and identifies missing data for regulatory compliance.

## Key findings

- Ziram's use as a fungicide on plum, pear, and peach trees was evaluated for regulatory risk assessment.
- Maximum residue levels in pear were assessed, and reliable endpoints were identified.
- Concerns and missing information required by EU regulations were highlighted.

## Abstract

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Italy, and co‐rapporteur Member State, Malta, for the pesticide active substance ziram and the assessment of applications for maximum residue levels (MRLs) are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative uses of ziram as a fungicide on plum, pear and peach trees. MRLs were assessed in pear. The reliable end points, appropriate for use in regulatory risk assessment, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

## Linked entities

- **Chemicals:** ziram (PubChem CID 8722)

## Full-text entities

- **Genes:** AR (androgen receptor) [NCBI Gene 367] {aka AIS, AR8, DHTR, HPCX3, HUMARA, HYSP1}, CALML3 (calmodulin like 3) [NCBI Gene 810] {aka CLP}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, RARA (retinoic acid receptor alpha) [NCBI Gene 5914] {aka NR1B1, RAR, RARalpha}
- **Diseases:** DNT (MESH:D020258), tumours (MESH:D009369), AAOEL (MESH:D010149), chromosomal aberration (MESH:D002869), poisoning (MESH:D011041), Eye Dam (MESH:D005134), atrophic changes (MESH:D020966), inflammation (MESH:D007249), muscular atrophy (MESH:D009133), CONDITIONS (MESH:D020763), EEC (MESH:C565062), muscle (MESH:D019042), Parkinson's disease (MESH:D010300), Acute Tox (MESH:D000208), acute and long-term toxicity (MESH:D000069451), visceral anomalies (MESH:D007418), bodyweight gain (MESH:D015430), phototoxic (MESH:D017484), FOB (MESH:D003291), ED (MESH:D004700), MAMMALIAN (MESH:C000655084), RMS (MESH:C535541), LOAEL (MESH:D064420), ENVIRONMENTAL (MESH:D018876), AOEL (MESH:D003789), carcinogenic (MESH:D011230), ataxia (MESH:D001259), Neuropathy (MESH:D009422), TRIGGERING (MESH:D052582), diaphragmatic thinning (MESH:D013851), OTHER OUTSTANDING ISSUES (MESH:D058497), degeneration (MESH:D009410), RESIDUES (MESH:D018365), skeletal anomalies (MESH:C535534)
- **Chemicals:** lactose (MESH:D007785), N (MESH:D009584), N-chloro-dimethylamine (MESH:C570700), 14C (MESH:C000615234), acetonitrile (MESH:C032159), substance (MESH:C012600), DMA (MESH:C034516), C (MESH:D002244), S-glucuronide (MESH:D020719), T (MESH:D014316), phosphorus (MESH:D010758), M7 (MESH:C009957), acid (MESH:D000143), drinking water (MESH:D060766), CS2 (MESH:D002246), nitrosamine (MESH:D009602), COS (MESH:C010063), water (MESH:D014867), DMDC (MESH:C040863), Ziram (MESH:D015039), DT (MESH:D013936), oil (MESH:D009821), 1,1-dimethyl urea (MESH:C018275), T4 (MESH:D013974), N,N-dimethyldithiocarbamate (-), nitrile (MESH:D009570), Thiram (MESH:D013893), epoxide (MESH:D004852), Arsenic (MESH:D001151), AR (MESH:D001128), calcium (MESH:D002118), M8 (MESH:C017233), Tetramethylthiuram monosulfide (MESH:C034033), PEC (MESH:C058575), carbon dioxide (MESH:D002245)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], earthworms (species) [taxon 71170], Canis lupus familiaris (dog, subspecies) [taxon 9615], Pyrus communis (pear, species) [taxon 23211], Malus domestica (apple, species) [taxon 3750], Stemphylium vesicarium (species) [taxon 119933], Kampimodromus aberrans (species) [taxon 425259], Prunus persica (peach, species) [taxon 3760], Aphidius rhopalosiphi (species) [taxon 55891], Venturia pyrina (species) [taxon 415593], Wilsonomyces carpophilus (species) [taxon 763997], Daphnia magna (species) [taxon 35525], Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606], Taphrina deformans (peach leaf curl fungus, species) [taxon 5011], Monilia fructigena (species) [taxon 503105], Typhlodromus pyri (species) [taxon 84387], Apis mellifera (bee, species) [taxon 7460], Oryctolagus cuniculus (domestic rabbit, species) [taxon 9986], Metaphire sieboldi (earthworm, species) [taxon 506672], Prunus domestica (plum, species) [taxon 3758], PX clade (clade) [taxon 569578]

## Full text

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## Figures

16 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12930216/full.md

## References

41 references — full list in the complete paper: https://tomesphere.com/paper/PMC12930216/full.md

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Source: https://tomesphere.com/paper/PMC12930216