# Metastatic Melanoma Mimicking Primary Breast Cancer—A Diagnostic Challenge: A Case Report

**Authors:** Angela de Salles Rezende, Teresa Cristina Ferreira Gutman, Marcus Vinicius Teixeira Calejon Stumpf, Karin Soares Gonçalves Cunha, Fabiana Resende Rodrigues, Vânia Gloria Silami Lopes

PMC · DOI: 10.1155/crip/8820195 · Case Reports in Pathology · 2026-02-24

## TL;DR

A case report highlights how metastatic melanoma can mimic primary breast cancer, emphasizing the need for careful diagnosis.

## Contribution

The novelty lies in presenting a rare case of metastatic melanoma in the breast, underscoring diagnostic challenges.

## Key findings

- Metastatic melanoma can appear as a breast nodule and be mistaken for primary breast cancer.
- Accurate diagnosis requires histological and immunohistochemical analysis along with clinical history.
- The patient's history of melanoma and atypical presentation were key to identifying the metastasis.

## Abstract

Metastatic melanoma to the breast is rare and may be misdiagnosed as primary breast carcinoma. Histological, immunohistochemical, and clinical correlations, such as a history of previous melanoma, are essential for diagnosis.

A female patient presented with melanoma in the left gluteal region. Five years later, a palpable nodule was detected in the right breast on routine mammography. Microscopic and immunohistochemical examination confirmed the diagnosis of metastatic melanoma. The patient passed away 3 years later.

The findings in this case indicate that metastatic melanoma can present in atypical ways and that specialists should pay attention to metastases in unusual locations in cases of melanoma.

## Linked entities

- **Diseases:** metastatic melanoma (MONDO:0005191)

## Full-text entities

- **Genes:** CLTA (clathrin light chain A) [NCBI Gene 1211] {aka LCA}, MLANA (melan-A) [NCBI Gene 2315] {aka MART-1, MART1}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}
- **Diseases:** seizure (MESH:D012640), neuroendocrine tumors (MESH:D018358), sarcomas (MESH:D012509), organ failure (MESH:D009102), bleeding (MESH:D006470), lung (MESH:D008171), malignancies (MESH:D009369), disease (MESH:D004194), inflammatory (MESH:D007249), fibrosis (MESH:D005355), Malignant melanoma (MESH:D008545), solar elastosis (MESH:D000092130), necrosis (MESH:D009336), cutaneous melanoma (MESH:C562393), lymphoma (MESH:D008223), steatonecrosis (MESH:D005218), Breast Cancer (MESH:D001943), primary (MESH:D010538), breast melanoma (MESH:D061325), melanoma metastases (MESH:D009362)
- **Chemicals:** eosin (MESH:D004801), melanin (MESH:D008543), Hematoxylin (MESH:D006416)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12930203/full.md

## References

26 references — full list in the complete paper: https://tomesphere.com/paper/PMC12930203/full.md

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Source: https://tomesphere.com/paper/PMC12930203