# Idiopathic Adrenal Hematoma as an Unusual Cause of Acute Abdomen: A Case Report

**Authors:** Anas E Ahmed, Khalid F Alreshidi, Esraa H Al Muaddil, Shahad M Alyami, Raghad H Alsayed

PMC · DOI: 10.7759/cureus.102235 · Cureus · 2026-01-24

## TL;DR

A rare case of idiopathic adrenal hematoma mimicking acute abdomen is reported, emphasizing the importance of imaging and conservative management.

## Contribution

This case report adds to the limited literature on idiopathic adrenal hematoma and its management without surgery.

## Key findings

- The patient's symptoms resolved with conservative management and no underlying adrenal pathology was found.
- Imaging confirmed acute adrenal hemorrhage without evidence of trauma or systemic disease.
- Interval imaging showed regression of the adrenal lesion, supporting the idiopathic diagnosis.

## Abstract

Idiopathic adrenal hematoma is a rare and diagnostically challenging condition that may present as an acute abdomen and closely resemble more common surgical and medical emergencies. We report a case of a 45-year-old male who presented with a sudden onset of severe abdominal pain in the absence of trauma, anticoagulant use, or any known systemic disease. Physical examination revealed localized abdominal tenderness, and routine laboratory investigations, including hematological, biochemical, coagulation, and endocrine testing, were within normal limits. Cross-sectional imaging demonstrated findings consistent with acute adrenal hemorrhage, with no evidence of an underlying functional or malignant adrenal lesion. The patient was managed conservatively with analgesia, close clinical observation, and multidisciplinary care, resulting in an uncomplicated clinical course and progressive symptom resolution. Interval imaging showed regression of the adrenal lesion, supporting the diagnosis of idiopathic adrenal hematoma. This report highlights the importance of considering adrenal hemorrhage in the differential diagnosis of acute abdominal pain, the role of imaging and hormonal evaluation in excluding secondary causes, and the utility of non-operative management with appropriate follow-up in clinically stable patients.

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, POMC (proopiomelanocortin) [NCBI Gene 5443] {aka ACTH, CLIP, LPH, MSH, NPP, OBAIRH}, REN (renin) [NCBI Gene 5972] {aka ADTKD4, HNFJ2, RTD}
- **Diseases:** nausea (MESH:D009325), microvascular fragility (MESH:D017566), reperfusion injury (MESH:D015427), adrenal vein thrombosis (MESH:D012170), abdominal distension (MESH:D000007), acute adrenal hemorrhage (MESH:D000081032), bleeding (MESH:D006470), Idiopathic Adrenal Hematoma (MESH:D006406), bowel or (MESH:D012778), organomegaly (MESH:D016878), trauma (MESH:D014947), skin bruising (MESH:D003288), Inflammatory (MESH:D007249), appendicitis (MESH:D001064), headaches (MESH:D006261), tenderness (MESH:D063806), venous congestion (MESH:D006940), palpitations (MESH:D006331), adrenal abnormality (MESH:D000224), pain (MESH:D010146), endocrine tumors (MESH:D004701), hypertension (MESH:D006973), vascular abnormalities (MESH:D014652), rigidity (MESH:D009127), fever (MESH:D005334), acute anemia (MESH:D000208), malignancy (MESH:D009369), endocrine abnormalities (MESH:D004700), adrenal disease (MESH:D000307), calcification (MESH:D002114), chills (MESH:D023341), acute adrenal insufficiency (MESH:D000309), hypotension (MESH:D007022), coagulopathy (MESH:D001778), Abdomen (MESH:D000006), adrenal (MESH:D000310), sepsis (MESH:D018805), systemic disease (MESH:D034721), hemorrhagic shock (MESH:D012771), vomiting (MESH:D014839), renal stones (MESH:D007669), antiphospholipid syndrome (MESH:D016736), metastatic disease (MESH:D000092182), Adrenal hemorrhage (MESH:D014884), abdominal or flank pain (MESH:D015746), weight loss (MESH:D015431), adrenal mass (MESH:C536030)
- **Chemicals:** steroid (MESH:D013256), Muaddil (-), oxygen (MESH:D010100), cortisol (MESH:D006854), alcohol (MESH:D000438), catecholamine (MESH:D002395), metanephrines (MESH:D008676), normetanephrines (MESH:D009647), aldosterone (MESH:D000450)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12930114/full.md

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Source: https://tomesphere.com/paper/PMC12930114