# DoE‐It‐Yourself (DoEIY): An Open‐Access Web Application for Democratizing Experimental Design in Chemical and Materials Research

## TL;DR

DoEIY.app is a free web tool that simplifies experimental design for chemical and materials research, making it more accessible and reproducible.

## Contribution

The novel contribution is an open-access web application that democratizes the use of Design of Experiments (DoE) in scientific research.

## Key findings

- DoEIY.app supports guided design generation and interactive model exploration through an intuitive interface.
- Case studies on gold nanoparticle synthesis demonstrate the tool's effectiveness in optimizing particle size dispersity and diameter.
- The application enables efficient and reproducible process optimization across scientific domains.

## Abstract

Achieving predictable and reproducible outcomes is a central challenge across synthetic workflows. Design of Experiments (DoE) offers a structured, multivariate framework for exploring complex parameter spaces, yet its wider adoption has been limited by statistical complexity, licensing costs, and steep learning curves. To address these barriers, we introduce DoEIY.app, an open‐access web application that streamlines the experimental design process. The software supports guided design generation, data entry and analysis, and interactive model exploration through an intuitive interface. We illustrate its use in two case studies on gold nanoparticle synthesis, focusing on minimizing size dispersity and controlling mean particle diameter. These examples demonstrate how DoEIY.app enables efficient, reproducible process optimization and highlight its potential to democratize DoE implementation across a broad range of scientific domains.

Reproducible and efficient experimental workflows remain a persistent challenge in chemical and materials research. Design of Experiments (DoE) provides a powerful multivariate framework but is often limited by complexity and accessibility. DoEIY.app is a free, browser‐based web application that enables guided experimental design, analysis, and interactive model exploration, demonstrated through gold nanoparticle synthesis case studies.