# Stilbenoid gaylussacin modulates particulate matter-induced chromatin remodeling in macrophages to suppress chronic obstructive pulmonary disease

**Authors:** Jeong Yeon Sim, Jee Hwan Ahn, Hye-Young Min, Jae-Hwan Kwak, Suckchang Hong, Dae-Duk Kim, Ho-Young Lee

PMC · DOI: 10.1038/s41392-026-02579-7 · Signal Transduction and Targeted Therapy · 2026-02-24

## Full-text entities

- **Genes:** SMC1A (structural maintenance of chromosomes 1A) [NCBI Gene 8243] {aka CDLS2, DEE85, DXS423E, EIEE85, SB1.8, SMC1}, Csnk2a2 (casein kinase 2, alpha prime polypeptide) [NCBI Gene 13000] {aka 1110035J23Rik, CK2}, Ctcf (CCCTC-binding factor) [NCBI Gene 13018], Sirt1 (sirtuin 1) [NCBI Gene 93759] {aka SIR2L1, Sir2, Sir2a, Sir2alpha}, Kmo (kynurenine 3-monooxygenase) [NCBI Gene 98256], SMC3 (structural maintenance of chromosomes 3) [NCBI Gene 9126] {aka BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1}, Gpt (glutamic pyruvic transaminase, soluble) [NCBI Gene 76282] {aka 1300007J06Rik, 2310022B03Rik, ALT, ALT1, Gpt-1, Gpt1}, STAG1 (STAG1 cohesin complex component) [NCBI Gene 10274] {aka MRD47, SA1, SCC3A}, STAG2 (STAG2 cohesin complex component) [NCBI Gene 10735] {aka HPE13, MKMS, NEDXCF, SA-2, SA2, SCC3B}, CTCF (CCCTC-binding factor) [NCBI Gene 10664] {aka CFAP108, FAP108, MRD21}, Slc17a5 (solute carrier family 17 (anion/sugar transporter), member 5) [NCBI Gene 235504] {aka 4631416G20Rik, 4732491M05, AST, ISSD, NSD, SD}
- **Diseases:** inflammation (MESH:D007249), emphysema (MESH:D004646), chronic bronchitis (MESH:D029481), lung deterioration (MESH:D008171), COPD (MESH:D029424), PM (MESH:D056784), cytotoxicity (MESH:D064420), proinflammatory gene (MESH:C537680)
- **Chemicals:** P (MESH:D010758), pterostilbene (MESH:C107773), Stilbenoid (MESH:D013267), pinostilbene (MESH:C522997), Gaylussacin (MESH:C001275), piceatannol (MESH:C041525), silmitasertib (MESH:C555142), aglycone (MESH:C458179), kynurenine (MESH:D007737), resveratrol (MESH:D000077185), oxyresveratrol (MESH:C034912), NO (MESH:D009614), CS (-), rhapontin (MESH:C023538), ATP (MESH:D000255), threonine (MESH:D013912), DMSO (MESH:D004121), RNS (MESH:D011886), NAD+ (MESH:D009243)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** RPE — Homo sapiens (Human), Telomerase immortalized cell line (CVCL_4388), HT-22 — Mus musculus (Mouse), Transformed cell line (CVCL_0321), MH-S — Mus musculus (Mouse), Transformed cell line (CVCL_3855), MLg — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_0437), MLE-12 — Mus musculus (Mouse), Transformed cell line (CVCL_3751)

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Source: https://tomesphere.com/paper/PMC12929684