# Jaceidin Suppresses Melanoma Metastasis by Modulating ERK, JNK Pathways and Extracellular Matrix Degradation Proteins

## TL;DR

Jaceidin, a flavonoid compound, shows anti-melanoma effects by inhibiting cancer cell metastasis through specific molecular pathways.

## Contribution

This study reveals jaceidin's novel anti-metastatic effects on melanoma cells via ERK, JNK pathways and extracellular matrix proteins.

## Key findings

- Jaceidin significantly inhibits metastasis in HMY-1 and A2058 melanoma cell lines.
- Jaceidin modulates ERK and JNK phosphorylation and suppresses epithelial-mesenchymal transition proteins.
- Jaceidin reduces expression of MMP-2 and cathepsins A, which degrade extracellular matrix.

## Abstract

Metastatic melanoma, marked by its poor prognosis and frequent recurrence, is a particularly aggressive skin cancer. Jaceidin, a compound derived from flavonoids abundant in common fruits and vegetables, has attracted interest for its potential anti‐cancer properties. Nevertheless, the specific effects of jaceidin on melanoma cells remained unclear before this study. Here, we examined the impact of jaceidin on two metastatic melanoma cell lines, HMY‐1 and A2058. Our results demonstrate that jaceidin exerts a significant anti‐metastatic effect against both cell lines. This inhibitory action involved modulating the phosphorylation of extracellular signal‐regulated kinase and c‐Jun N‐terminal kinase, as well as suppressing proteins associated with epithelial‐mesenchymal transition. Furthermore, jaceidin reduced the expression of extracellular matrix degradation proteins MMP‐2 and cathepsins A. These compelling findings suggest that jaceidin warrants further investigation as a potential therapeutic agent for melanoma.