# A Case of Aseptic Meningitis Presenting With Widespread Non‐Dermatomal Neuropathic Pain

**Authors:** Jun Komoda

PMC · DOI: 10.1002/jgf2.70107 · Journal of General and Family Medicine · 2026-02-23

## TL;DR

A 62-year-old man with ulcerative colitis developed widespread neuropathic pain, which was later linked to aseptic meningitis.

## Contribution

This case report highlights a rare presentation of aseptic meningitis causing non-dermatomal neuropathic pain.

## Key findings

- Aseptic meningitis was confirmed via cerebrospinal fluid analysis and brain MRI.
- The patient's pain improved with oral analgesics.
- Other conditions like vitamin B12 deficiency and cervical spondylotic myelopathy were present but not the cause of the pain.

## Abstract

Aseptic meningitis occasionally causes neuropathic pain in a dermatomal distribution, but widespread non‐dermatomal pain is extremely rare. We report a case of a 62‐year‐old man with ulcerative colitis who developed neuropathic pain involving the head, trunk, and limbs. Cerebrospinal fluid analysis and brain MRI confirmed aseptic meningitis. Although vitamin B12 deficiency and cervical spondylotic myelopathy were present, they did not explain the symptoms. The pain improved with oral analgesics. This case highlights aseptic meningitis as a possible cause of non‐dermatomal neuropathic pain.

## Linked entities

- **Diseases:** aseptic meningitis (MONDO:0006662), ulcerative colitis (MONDO:0005101), vitamin B12 deficiency (MONDO:0020696)

## Full-text entities

- **Genes:** AQP4 (aquaporin 4) [NCBI Gene 361] {aka MIWC, MLC4, WCH4, hAQP4}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, ADA (adenosine deaminase) [NCBI Gene 100] {aka ADA1}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** Aseptic Meningitis (MESH:D008582), numbness (MESH:D006987), viral infection (MESH:D014777), hypertension (MESH:D006973), chronic (MESH:D002908), autoimmune or infectious neuropathies (MESH:D003141), Ulcerative colitis (MESH:D003093), migraine (MESH:D008881), Tactile allodynia (MESH:D006930), viral meningitis (MESH:D008587), TB (MESH:D014390), tuberculosis (MESH:D014376), infarct (MESH:D007238), Neuropathic Pain (MESH:D009437), Meningitis (MESH:D008580), central nervous system disorders (MESH:D002493), hyponatremia (MESH:D007010), neck stiffness (MESH:D006258), spinal canal stenosis (MESH:D013130), psychiatric (MESH:D001523), sinusitis (MESH:D012852), skin eruptions (MESH:D012871), Pain (MESH:D010146), CSF abnormalities (MESH:D002559), Epstein-Barr virus (MESH:D020031), neural injury (MESH:D014947), inflammation (MESH:D007249), headache (MESH:D006261), cervical spondylotic myelopathy (MESH:D002575), fever (MESH:D005334), spinal cord disorders (MESH:D013118), neurological deficits (MESH:D009461), metabolic diseases (MESH:D008659), postherpetic (MESH:D051474), vitamin B12 deficiency (MESH:D014806), nausea (MESH:D009325), cytomegalovirus (MESH:D003586), tachycardia (MESH:D013610), urticaria (MESH:D014581), lymphadenopathy (MESH:D008206), rashes (MESH:D005076), myelitis (MESH:D009187)
- **Chemicals:** Ceftriaxone (MESH:D002443), pregabalin (MESH:D000069583), glucose (MESH:D005947), vitamin B12 (MESH:D014805), amitriptyline (MESH:D000639), loxoprofen (MESH:C040656), mesalazine (MESH:D019804), clarithromycin (MESH:D017291), acyclovir (MESH:D000212)
- **Species:** Homo sapiens (human, species) [taxon 9606], Streptococcus acidominimus (species) [taxon 1326], Human immunodeficiency virus 1 (no rank) [taxon 11676], Human alphaherpesvirus 3 (Varicella-zoster virus, no rank) [taxon 10335], Gammacoronavirus (genus) [taxon 694013]

## Full text

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12929655/full.md

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Source: https://tomesphere.com/paper/PMC12929655