# Case Report: Ovarian dysgerminoma with pseudo-Meigs syndrome in a child

**Authors:** Zhanhu Li, Dong Chen, Qiang Wei

PMC · DOI: 10.3389/fped.2026.1773364 · Frontiers in Pediatrics · 2026-02-10

## TL;DR

A 15-year-old girl with a rare ovarian tumor and pseudo-Meigs syndrome showed rapid improvement after surgery and chemotherapy.

## Contribution

This case report highlights the rare association between ovarian dysgerminoma and pseudo-Meigs syndrome in a pediatric patient.

## Key findings

- Surgical resection led to rapid resolution of pleural and ascitic effusions.
- Postoperative chemotherapy resulted in full recovery with no recurrence over 9 months.
- The case underscores the importance of considering rare tumor associations in pediatric gynecological presentations.

## Abstract

Ovarian dysgerminoma is a rare pediatric germ cell tumor, and its association with pseudo-Meigs syndrome (PMS) is exceedingly uncommon. PMS is characterized by massive pleural effusions and ascites accompanying a pelvic mass, which often leads to clinical misdiagnosis. This report describes the case of a 15-year-old female patient who presented with abdominal distension, chest tightness, and significant pleural and ascitic effusions. Following surgical resection of the tumor, the effusions resolved rapidly. Postoperative pathology confirmed the diagnosis of ovarian dysgerminoma. The patient received adjuvant chemotherapy post-surgery, recovered well, and showed no evidence of recurrence during a 9-month follow-up period.

## Linked entities

- **Diseases:** ovarian dysgerminoma (MONDO:0003481), pseudo-Meigs syndrome (MONDO:0017800)

## Full-text entities

- **Genes:** AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}, MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, CGB5 (chorionic gonadotropin subunit beta 5) [NCBI Gene 93659] {aka CGB, HCG}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, TNFRSF8 (TNF receptor superfamily member 8) [NCBI Gene 943] {aka CD30, D1S166E, Ki-1}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, ENO2 (enolase 2) [NCBI Gene 2026] {aka HEL-S-279, NSE}, CALB2 (calbindin 2) [NCBI Gene 794] {aka CAB29, CAL2, CR}, PLAA (phospholipase A2 activating protein) [NCBI Gene 9373] {aka DOA1, NDMSBA, PLA2P, PLAP}
- **Diseases:** Tuberculous pleurisy (MESH:D014396), inflammation (MESH:D007249), Ascites (MESH:D001201), disease (MESH:D004194), Malignant pleural metastasis (MESH:D009362), Dysgerminoma (MESH:D004407), cough (MESH:D003371), effusion (MESH:D000080324), Tumor (MESH:D009369), peritoneal (MESH:D010538), pulmonary or pleural lesions (MESH:D008171), rupture (MESH:D012421), malignant ovarian tumor (MESH:D010051), Pleural effusion (MESH:D010996), non-fibroma/non-fibroma-like tumors (MESH:D005350), abdominal distension (MESH:D000007), hemorrhage (MESH:D006470), pelvic mass (MESH:C536030), paraneoplastic effusions (MESH:D010257), Meigs (MESH:D008538), Ovarian dysgerminoma (MESH:D010049), necrosis (MESH:D009336), fever (MESH:D005334), germ cell tumor (MESH:D009373)
- **Chemicals:** Hematoxylin (MESH:D006416), cisplatin (MESH:D002945), Platinum (MESH:D010984), etoposide (MESH:D005047), Estradiol (MESH:D004958), eosin (MESH:D004801), H (MESH:D006859), BEP (MESH:C038328), bleomycin (MESH:D001761)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12929488/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12929488/full.md

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Source: https://tomesphere.com/paper/PMC12929488