# Commentary: Physiological effects of bi-level high-flow nasal cannula in healthy individuals: a proof of concept trial

**Authors:** Adrián Gallardo, Armando Díaz-Cabrera, Mauro Castro-Sayat

PMC · DOI: 10.3389/fmed.2026.1774347 · Frontiers in Medicine · 2026-02-10

## Full-text entities

- **Diseases:** lung injury (MESH:D055370), tachypnea (MESH:D059246), EELV (MESH:D008171), critically ill (MESH:D016638), alveolar collapse (MESH:D001261), hypoxemia (MESH:D000860), fatigue (MESH:D005221), diaphragmatic (MESH:D006548), ARF (MESH:D012131), obstructive sleep apnea (MESH:D020181)
- **Chemicals:** C- (MESH:D002244), Bi (MESH:D001729), HFNC (-), CO2 (MESH:D002245)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12929438/full.md

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Source: https://tomesphere.com/paper/PMC12929438