# Clinical outcomes of unilateral biportal endoscopic discectomy vs. microdiscectomy in lumbar disc herniation

**Authors:** Yi He, Peng-fei Cao, Yin Zhang, Xun-an Xu, Tong-guang Xu

PMC · DOI: 10.3389/fmed.2026.1758130 · Frontiers in Medicine · 2026-02-10

## TL;DR

This study compares two minimally invasive surgeries for lumbar disc herniation and finds that endoscopic surgery offers faster recovery and less blood loss.

## Contribution

The study provides comparative clinical outcomes of UBE and MSLD for LDH treatment in a single-center retrospective analysis.

## Key findings

- UBE surgery was associated with shorter operation times, less blood loss, and shorter hospital stays compared to MSLD.
- UBE showed better early pain relief and functional recovery at 3 days, 3 months, and 6 months post-surgery.
- UBE preserved intervertebral space height better at 6 months compared to MSLD.

## Abstract

Lumbar disc herniation (LDH) often causes radiculopathy, resulting in unilateral leg pain and lower back discomfort. Minimally invasive techniques such as microscopic discectomy (MSLD) and unilateral biportal endoscopic (UBE) discectomy are widely used. However, comparative data are limited. This study compares the clinical outcomes and complications of UBE and MSLD.

A single-center, retrospective, non-randomized analysis was conducted on 80 patients with LDH who underwent surgical treatment at People’s Hospital of Suzhou New District between January 2021 and September 2023. Patients were categorized according to the surgical technique received into a microscope group (MG, n = 38) and endoscopic group (EG, n = 42). Pre- and postoperative pain (VAS), functional recovery (ODI, JOA), and intervertebral space height were assessed. Postoperative efficacy and complication rates were evaluated at a 6-month follow-up.

Compared with MG, the EG group was associated with shorter operation and hospitalization times and less intraoperative blood loss (p = 0.03, p = 0.02). VAS, ODI, and JOA scores improved over time in both groups, with greater early improvements observed in EG at 3 days, 3 months, and 6 months postoperatively (p = 0.04, p = 0.01, p = 0.02). At 6 months, EG was also associated with better preservation of intervertebral space height (p = 0.04). No statistically significant differences were observed between groups in terms of overall clinical efficacy or postoperative complication rates (p > 0.05).

Both UBE and MSLD are effective surgical options for the treatment of LDH. The findings suggest that UBE may offer advantages in surgical efficiency, early pain relief, functional recovery, and intervertebral space preservation. Given the retrospective, non-randomized design, selection bias and residual confounding cannot be entirely excluded, so these associative findings require confirmation in prospective studies with longer follow-up.

## Linked entities

- **Diseases:** radiculopathy (MONDO:0002959)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, COX2 (cytochrome c oxidase subunit II) [NCBI Gene 4513] {aka COII, MTCO2}
- **Diseases:** cauda equina syndrome (MESH:D011128), hematomas (MESH:D006406), muscle atrophy (MESH:D009133), inflammation (MESH:D007249), collapse of the intervertebral space (MESH:D001261), Complications (MESH:D008107), ODI (MESH:C566784), trauma (MESH:D014947), sciatica (MESH:D012585), back pain (MESH:D001416), CSF leaks (MESH:D002559), blood (MESH:D006402), leg pain (MESH:D010146), hypertension (MESH:D006973), LDH (MESH:C535531), MG (MESH:D046728), spinal tumor (MESH:D009369), postoperative chronic pain (MESH:D010149), weakness (MESH:D018908), diabetes mellitus (MESH:D003920), MED (MESH:D010009), lumbar spondylolisthesis (MESH:D013168), mental illness (MESH:D001523), osteoporotic (MESH:D058866), blood loss (MESH:D016063), nerve root adhesion (MESH:D011843), lumbar fractures (MESH:C563613), numbness (MESH:D006987), chronic pain (MESH:D059350), disc degeneration (MESH:D055959), obese (MESH:D009765), bleeding (MESH:D006470), spinal tuberculosis (MESH:D014399), lumbar sprain (MESH:D013180), ankylosing spondylitis (MESH:D013167), PELD (OMIM:615924), hyperplasia of the ligamentum flavum (MESH:D006965), Dural tears (MESH:D020785), herniation (MESH:D004677), myodynamia deficits (MESH:D009461), spinal deformity (MESH:D013122), low back and lower limb pain (MESH:D017116), UBE (MESH:D046088), cognitive impairment (MESH:D003072)
- **Chemicals:** EG (-), paracetamol (MESH:D000082), steroid (MESH:D013256), alcohol (MESH:D000438)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12929403/full.md

## References

66 references — full list in the complete paper: https://tomesphere.com/paper/PMC12929403/full.md

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Source: https://tomesphere.com/paper/PMC12929403