# Refractory Hyperkinetic Biliary Colic: A Case of Biliary Dyskinesia

**Authors:** Brielle Coe, Iman Elkhashab, Mian Arsam Haroon, Charles N Frasso

PMC · DOI: 10.7759/cureus.102226 · Cureus · 2026-01-24

## TL;DR

A rare case of hyperkinetic biliary dyskinesia is described, where a patient's symptoms improved after gallbladder removal.

## Contribution

This paper presents a rare clinical case of hyperkinetic biliary dyskinesia and its successful treatment via cholecystectomy.

## Key findings

- A 48-year-old female with hyperkinetic biliary dyskinesia showed 100% gallbladder ejection on HIDA scan.
- Symptoms improved after robotic-assisted cholecystectomy.
- The case highlights the diagnostic and management challenges of this rare condition.

## Abstract

Biliary dyskinesia results from abnormal gallbladder motility, leading to a deviation from a physiologic biliary ejection fraction. It is classified into two types: hyperkinetic and hypokinetic. Hyperkinetic biliary dyskinesia is an uncommon condition that may present without symptoms. In clinical practice, some patients are noted to have elevated gallbladder ejection fractions, though only a minority are considered for intervention. Due to its rarity and variable presentation, there are currently no established guidelines for treatment.

We present the case of a 48-year-old female with a year-long history of postprandial right upper quadrant (RUQ) pain, nausea, and weight loss, ultimately diagnosed with hyperkinetic biliary colic. Following a comprehensive evaluation, which included unremarkable imaging and a hepatobiliary iminodiacetic acid (HIDA) scan demonstrating 100% gallbladder ejection. In the following days, she underwent robotic-assisted cholecystectomy (RAC) with subsequent symptomatic improvement. This case highlights the diagnostic challenges, management considerations, and postoperative outcomes based on the detailed personal account in this rare clinical entity.

## Linked entities

- **Diseases:** biliary dyskinesia (MONDO:0005667)

## Full-text entities

- **Genes:** CCK (cholecystokinin) [NCBI Gene 885]
- **Diseases:** Hyperkinetic (MESH:D006948), fever (MESH:D005334), Biliary Colic (MESH:D003085), vomiting (MESH:D014839), pruritus (MESH:D011537), dysuria (MESH:D053159), nausea (MESH:D009325), cholecystitis (MESH:D002764), -type (MESH:D006969), diarrhea (MESH:D003967), hypokinetic (MESH:D004401), diverticulitis (MESH:D004238), calculi (MESH:D002137), cystic duct injury (MESH:D018297), pancreatitis (MESH:D010195), sphincter of Oddi dysfunction (MESH:D046628), abdominal pain (MESH:D015746), abnormal gallbladder motility (MESH:D005705), gastrointestinal symptoms (MESH:D012817), GERD (MESH:D005764), incisional pain (MESH:D000069290), RUQ pain (MESH:D010146), dyspepsia (MESH:D004415), mucosal damage (MESH:D052016), postoperative nausea (MESH:D020250), IBS (MESH:D043183), constipation (MESH:D003248), loss of appetite (MESH:D001068), biliary obstruction (MESH:D001658), tenderness (MESH:D063806), biliary ductal dilation (MESH:D015529), chills (MESH:D023341), gallbladder or gastrointestinal disorders (MESH:D005767), infection (MESH:D007239), HIDA (MESH:D004066), weight loss (MESH:D015431), Biliary Dyskinesia (MESH:D001657), respiratory symptoms (MESH:D012818)
- **Chemicals:** iminodiacetic acid (MESH:C008109), bilirubin (MESH:D001663), alcohol (MESH:D000438), omeprazole (MESH:D009853), HIDA (-), oxycodone (MESH:D010098)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12929200/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12929200/full.md

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Source: https://tomesphere.com/paper/PMC12929200