# Differential causes of masticatory muscle disorders in dogs: a review of diagnosis, treatment and long-term management

**Authors:** Rachelle Fisher, Stephanie Goldschmidt, Marguerite F. Knipe, Maria Soltero-Rivera, Natalia Vapniarsky, Boaz Arzi

PMC · DOI: 10.3389/fvets.2026.1750095 · Frontiers in Veterinary Science · 2026-02-10

## TL;DR

This paper reviews the causes, diagnosis, and treatment of masticatory muscle disorders in dogs, highlighting the need for timely intervention and further research.

## Contribution

The paper synthesizes existing literature to provide a comprehensive overview and identifies gaps requiring further study.

## Key findings

- Masticatory muscle disorders in dogs can lead to life-threatening complications if not promptly diagnosed and treated.
- The paper highlights the complexity of these disorders due to multiple potential local and systemic causes.
- Current veterinary practices often rely on extrapolation from human medicine, indicating a need for more species-specific research.

## Abstract

Masticatory muscle disorders in the dog are complex and challenging cases to manage. Patients may present with inability or difficulties in opening or closing the mouth, making dysphagia and respiratory compromise major concerns. Time is of the essence in these circumstances, and prompt and accurate diagnosis and treatment are required to prevent potentially life-threatening complications from occurring. Several local and systemic disease processes may cause masticatory muscle dysfunction further complicating the diagnostic process. Current literature on masticatory muscle disorders is widespread with many recommendations in veterinary medicine extrapolated from human medicine. The goal of this paper is to synthesize the current literature and illuminate areas that require additional research.

## Full-text entities

- **Genes:** JAK1 (Janus kinase 1) [NCBI Gene 442952], MYH14 (myosin heavy chain 14) [NCBI Gene 79784] {aka DFNA4, DFNA4A, FP17425, MHC16, MYH17, NMHC II-C}, BMP1 (bone morphogenetic protein 1) [NCBI Gene 649] {aka OI13, PCOLC, PCP, TLD}, ACVR1 (activin A receptor type 1) [NCBI Gene 478757], COX2 (cytochrome c oxidase subunit II) [NCBI Gene 804479], ACVR1 (activin A receptor type 1) [NCBI Gene 90] {aka ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1}, CALCA (calcitonin related polypeptide alpha) [NCBI Gene 403946] {aka CALC, CCALCI, CGRP-I, CGRP1}, PTH (parathyroid hormone) [NCBI Gene 403986], PTGS2 (prostaglandin-endoperoxide synthase 2) [NCBI Gene 442942] {aka COX-2}
- **Diseases:** lordosis (MESH:D008141), myalgia (MESH:D063806), muscle necrosis (MESH:D009135), mandibular paralysis (MESH:D008338), aspiration pneumonia (MESH:D011015), congestive heart failure (MESH:D006333), stridor (MESH:D012135), facial asymmetry (MESH:D005146), PSML (MESH:D008223), cellulitis (MESH:D002481), musculoskeletal condition (MESH:D009140), Bacterial diseases (MESH:D001424), T. gondii infections (MESH:D014123), Parasitic cysts (MESH:D003560), hemophilia (MESH:D006467), Infectious (MESH:D003141), Tetanus (MESH:D013746), myasthenia gravis (MESH:D009157), necrotic tissue (MESH:D017695), tooth extraction (MESH:D014076), myofiber necrosis (MESH:D009336), prolonged muscle contraction (MESH:D008133), rigidity (MESH:D009127), Chagas disease (MESH:D014355), neutrophilia (MESH:C563010), inability to open the (MESH:D005597), canine distemper viral infections (MESH:D014777), nerve injury (MESH:D000080902), Death (MESH:D003643), spastic paralysis (MESH:C538358), hypertension (MESH:D006973), blood work abnormalities (MESH:D006402), masticatory (MESH:C563600), dysphagia (MESH:D003680), rheumatoid arthritis (MESH:D001172), spasm of the muscles of mastication (MESH:D013035), stone man syndrome (MESH:D016750), anemia (MESH:D000740), Both (MESH:C535620), concussive injuries (MESH:D056104), leukocytosis (MESH:D007964), extra-skeletal ossification (MESH:C562735), weight loss (MESH:D015431), compartment syndrome (MESH:D003161), PM (MESH:D017285), subcutaneous (MESH:D013352), Trypanosomiasis (MESH:D014352), Factor XI deficiency (MESH:D005173), Thrombocytopenia (MESH:D013921), Clostridial infections (MESH:D007239), dilated cardiomyopathy (MESH:D002311), myocarditis (MESH:D009205), dermatitis (MESH:D003872), odontogenic infections (MESH:D018126), radiculoneuropathy (MESH:C564857), Canine sarcocystosis (MESH:D012523), EOM (MESH:D009220), bleeding (MESH:D006470), neurologic disease (MESH:D020271), tachycardia (MESH:D013610)
- **Chemicals:** Prednisone (MESH:D011241), itraconazole (MESH:D017964), steroids (MESH:D013256), amiodarone (MESH:D000638), bisphosphonates (MESH:D004164), tetracycline (MESH:D013752), cyclosporin (MESH:D016572), prednisolone (MESH:D011239), N. caninum (-), leflunomide (MESH:D000077339), Magnesium sulphate (MESH:D008278), miltefosine (MESH:C039128), amphotericin B (MESH:D000666), Dexamethasone (MESH:D003907), acetylcholine (MESH:D000109), pyrimethamine (MESH:D011739), clindamycin (MESH:D002981), methotrexate (MESH:D008727), glycine (MESH:D005998), decoquinate (MESH:D003667), Oclacitinib (MESH:C588062), GABA (MESH:D005680), prednisolone acetate (MESH:C009935), allopurinol (MESH:D000493), azithromycin (MESH:D017963), doxycycline (MESH:D004318), mycophenolate mofetil (MESH:D009173), trimethoprim sulfadiazine (MESH:C024873), metronidazole (MESH:D008795), Azathioprine (MESH:D001379), amoxicillin-clavulanic acid (MESH:D019980), Glucantime (MESH:D000077485)
- **Species:** Hepatozoon americanum (species) [taxon 110119], Fusobacterium nucleatum (species) [taxon 851], Neospora caninum (species) [taxon 29176], Leptospira (genus) [taxon 171], Leishmania (subgenus) [taxon 38568], Homo sapiens (human, species) [taxon 9606], Ehrlichia canis (species) [taxon 944], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Hepatozoon canis (species) [taxon 110120], Trypanosoma cruzi (species) [taxon 5693], Clostridium tetani (species) [taxon 1513], Canis lupus familiaris (dog, subspecies) [taxon 9615]

## Full text

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## Figures

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## References

109 references — full list in the complete paper: https://tomesphere.com/paper/PMC12929153/full.md

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Source: https://tomesphere.com/paper/PMC12929153