# Study protocol for the Champaign-Urbana population study

**Authors:** Paul B. Camacho, Aaron T. Anderson, Rong Guo, Yuhui Chai, Sina Tafti, Ian Hall, Dominika M. Pindus, Chris Lockwood, Paul M. Arnold, Sheeba Arnold-Anteraper, Zhi-Pei Liang, Hacene Serrai, Andrew G. Webb, Bansari Upadhyay, Diane Beck, Mark D. Whiting, Bruce M. Damon, Tracey M. Wszalek, Brad P. Sutton

PMC · DOI: 10.3389/fnimg.2026.1728970 · Frontiers in Neuroimaging · 2026-02-10

## TL;DR

The Champaign Urbana Population Study (CUPS) aims to collect and share 7 Tesla MRI data from 200 adults to advance neuroimaging research and clinical applications.

## Contribution

CUPS introduces a publicly available database of high-resolution 7 T MRI data, including raw data, from a large adult cohort.

## Key findings

- 7 T MRI provides superior signal-to-noise ratio and contrast compared to lower field strengths.
- The study will publish a comprehensive database of structural, functional, and biochemical MRI data.
- Initial data collection has already produced example images demonstrating the potential of 7 T MRI.

## Abstract

Superior signal-to-noise ratio, enhanced and novel forms of contrast, and improved spectral resolution made possible by 7 Tesla (7 T) magnetic resonance imaging (MRI) offer great promise for both neuroimaging research and clinical practice. To characterize these gains, it is essential to acquire structural, functional, and biochemical 7 T MRI data from a large sample of adults. The Champaign Urbana Population Study (CUPS) will collect and publish a database of 7 T MRI data, including raw MRI data, from a cohort of up to 200 adults. Here, we describe the study design and provide example images from the initial round of data collection for CUPS.

## Full-text entities

- **Diseases:** NODDI (MESH:C564543), multiple sclerosis (MESH:D009103), cognitive decline (MESH:D003072), Hearing Handicap (MESH:D009422), age- (MESH:D019588), White matter lesion (MESH:D056784), temporal lobe epilepsy (MESH:D004833), brain atrophy (MESH:C566985), cerebral microbleeds (MESH:D002547)
- **Chemicals:** Ins (MESH:D007204), calcium (MESH:D002118), inositol (MESH:D007294), lipid (MESH:D008055), Cr (MESH:D002857), N-acetyl aspartate (MESH:C000179), creatine (MESH:D003401), Dipy (-), glutamate (MESH:D018698), Cho (MESH:C034482), PD (MESH:D010165), water (MESH:D014867), iron (MESH:D007501), choline (MESH:D002794), oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

9 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12929149/full.md

## References

198 references — full list in the complete paper: https://tomesphere.com/paper/PMC12929149/full.md

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Source: https://tomesphere.com/paper/PMC12929149