# A comprehensive review of clear cell stromal tumor of the lung: integrating clinicopathology and molecular pathogenesis

## TL;DR

This paper reviews a rare lung tumor called clear cell stromal tumor, focusing on its clinicopathological features and molecular characteristics.

## Contribution

The paper provides a comprehensive synthesis of current knowledge on a newly recognized and rare lung tumor.

## Key findings

- CCST is characterized by a YAP1::TFE3 gene fusion and specific histological features.
- Diagnosis is challenging due to the tumor's rarity and lack of specific markers beyond TFE3.
- Only thirty cases have been reported, highlighting the need for further research.

## Abstract

Clear cell stromal tumor (CCST) is a newly recognized mesenchymal neoplasm of the lung, with a recurrent YAP1::TFE3 gene fusion in most cases and characterized histologically by spindle, epithelioid cells, with variably clear to pale eosinophilic cytoplasm and prominent vascularity. Due to its rarity and the absence of specific immunohistochemical markers beyond TFE3, diagnosis remains challenging. Currently, only thirty cases have been documented. This narrative literature review synthesizes current advances to enhance understanding of this entity.