# Orbital Plasmacytoma as the Initial Presentation of Multiple Myeloma: A Case Report

**Authors:** Anais Panossian, Timmer Verhaegh, Aram A Namavar

PMC · DOI: 10.7759/cureus.102225 · Cureus · 2026-01-24

## TL;DR

This case report describes a rare orbital plasmacytoma as the first sign of multiple myeloma, highlighting the need for early diagnosis and proper treatment.

## Contribution

The paper presents a unique case of orbital plasmacytoma as an initial manifestation of multiple myeloma.

## Key findings

- Orbital plasmacytoma can be the initial presentation of multiple myeloma.
- Early diagnosis is crucial for effective treatment of this rare manifestation.

## Abstract

Multiple myeloma is a plasma cell dyscrasia that can lead to bone, renal, and hematologic complications. While multiple myeloma often manifests as a systemic disease, extramedullary manifestations can also occur in more advanced or aggressive forms of the disease. One of these manifestations is orbital plasmacytomas, which are rare and can often mimic other orbital pathologies, complicating diagnosis and treatment. This case report discusses a unique presentation of orbital plasmacytoma, emphasizing the importance of early diagnosis and tailored treatment.

## Linked entities

- **Diseases:** multiple myeloma (MONDO:0009693)

## Full-text entities

- **Genes:** SDC1 (syndecan 1) [NCBI Gene 6382] {aka CD138, SDC, SYND1, syndecan}, NCAM1 (neural cell adhesion molecule 1) [NCBI Gene 4684] {aka CD56, MSK39, NCAM}, CD38 (CD38 molecule) [NCBI Gene 952] {aka ADPRC 1, ADPRC1, cADPR1}, CD33 (CD33 molecule) [NCBI Gene 945] {aka CD33rSiglec, SIGLEC-3, SIGLEC3, p67}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}
- **Diseases:** idiopathic inflammatory disease (MESH:D009220), systemic disease (MESH:D034721), major depressive disorder (MESH:D003865), proptosis (MESH:D005094), fever (MESH:D005334), hematologic malignancy (MESH:D019337), sarcomas (MESH:D012509), bone pain (MESH:D010146), EMP (MESH:C537514), vision loss (MESH:D014786), Langerhans cell histiocytosis (MESH:D006646), inflammation (MESH:D007249), periorbital swelling (MESH:D006261), eyelid edema (MESH:D004487), MM (MESH:D009101), malignancy (MESH:D009369), left orbital mass (MESH:D009916), bipolar disorder (MESH:D001714), lymphoma (MESH:D008223), renal dysfunction (MESH:D007674), chondrosarcoma (MESH:D002813), plasma cell disorders (MESH:D007952), cytopenias (MESH:D006402), binocular diplopia (MESH:D004172), orbital neoplasms (MESH:D009918), anemia (MESH:D000740), malignant plasma cell disorder (MESH:D054219), displacement (MESH:D006617), bone lesions (MESH:D001847), hypercalcemia (MESH:D006934), weight loss (MESH:D015431), , and hematologic complications (MESH:D011250), Orbital Plasmacytoma (MESH:D010954), plasma cell dyscrasia (MESH:D010265)
- **Chemicals:** dorzolamide (MESH:C062765), methylprednisolone (MESH:D008775), erythromycin (MESH:D004917), timolol (MESH:D013999), gold (MESH:D006046), Daratumumab (MESH:C556306), prednisone (MESH:D011241), FDG (MESH:D019788)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12929035/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12929035/full.md

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Source: https://tomesphere.com/paper/PMC12929035