# Cephalalgia—A “Tricky” Symptom for the Cardiologist: Acute Coronary Syndrome Presenting as Headache

**Authors:** Alexandros Vassiliades, Varnavas Dimitriades, Vasiliki Vanesa Stylianou, Marios Pavlou, Panagiota Georgiou, Lorentzos Kapetis, Dimitrios Patestos, Michalis Tsielepis, George Bazoukis

PMC · DOI: 10.1002/ccr3.72066 · Clinical Case Reports · 2026-02-23

## TL;DR

Headaches can sometimes be the only sign of a heart attack, and doctors should consider this rare possibility.

## Contribution

Highlights the rare but critical presentation of acute coronary syndrome as a headache.

## Key findings

- Headache can be the primary symptom of acute myocardial ischemia.
- Electrocardiogram and cardiac biomarkers are essential for diagnosis in such cases.

## Abstract

Rarely, headache may be the primary or sole symptom of acute myocardial ischemia; clinicians should recognize such atypical presentations and obtain an electrocardiogram and cardiac biomarkers to establish the diagnosis and guide urgent treatment.

## Linked entities

- **Diseases:** acute coronary syndrome (MONDO:0005542)

## Full-text entities

- **Genes:** KNG1 (kininogen 1) [NCBI Gene 3827] {aka BDK, BK, HAE6, HK, HMWK, KNG}
- **Diseases:** ischemic (MESH:D002545), Headache Disorders (MESH:D020773), angina pectoris (MESH:D000787), Cardiac cephalalgia (MESH:D006261), dyslipidemia (MESH:D050171), pain (MESH:D010146), Acute Coronary Syndrome (MESH:D054058), stenosis (MESH:D003251), neurological deficits (MESH:D009461), malignant arrhythmias (MESH:D001145), nausea (MESH:D009325), ST-T abnormalities (MESH:D001260), myocardial ischemia (MESH:D017202), hypertension (MESH:D006973), photophobia (MESH:D020795), migraine (MESH:D008881), depression (MESH:D003866), heart failure (MESH:D006333), coronary artery disease (MESH:D003324)
- **Chemicals:** adenosine (MESH:D000241), histamine (MESH:D006632), nitrates (MESH:D009566), serotonin (MESH:D012701)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12929026/full.md

## References

3 references — full list in the complete paper: https://tomesphere.com/paper/PMC12929026/full.md

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Source: https://tomesphere.com/paper/PMC12929026