# Could targeting viruses be a new hope against neurodegenerative diseases?

**Authors:** Karin M. Danzer, Konstantin MJ Sparrer

PMC · DOI: 10.1371/journal.pbio.3003669 · PLOS Biology · 2026-02-13

## TL;DR

This paper explores whether targeting viruses through vaccines or antivirals could help prevent or treat neurodegenerative diseases like dementia.

## Contribution

The paper introduces the novel idea that viral triggers may contribute to dementia and that antiviral treatments could be a new preventive strategy.

## Key findings

- Current therapies for neurodegenerative diseases only modestly slow progression.
- Emerging evidence suggests vaccines and antivirals may reduce dementia risk by targeting viral triggers.

## Abstract

Despite decades of intensive research, our current approaches to treating neurodegenerative diseases only slow down the seemingly inevitable. Could recent data associating vaccinations with reduced risk of dementia offer an unexpected beacon of hope?

Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower dementia risk by targeting viral triggers, opening new avenues for prevention.

## Linked entities

- **Diseases:** dementia (MONDO:0001627)

## Full-text entities

- **Diseases:** neurodegenerative diseases (MESH:D019636), dementia (MESH:D003704)
- **Species:** Viruses (acellular root) [taxon 10239]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12928575/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12928575/full.md

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Source: https://tomesphere.com/paper/PMC12928575