# Could sleep engineering be used to combat PTSD and depression?

**Authors:** Penelope A. Lewis, Mahmoud E. A. Abdellahi

PMC · DOI: 10.1371/journal.pbio.3003633 · PLOS Biology · 2026-02-23

## TL;DR

This paper explores using sleep engineering, combined with machine learning, as a non-drug treatment for PTSD and depression.

## Contribution

The paper proposes using machine learning with EEG signals to detect memory reactivations during sleep for therapeutic purposes.

## Key findings

- Sleep engineering could offer a non-invasive treatment for PTSD and depression.
- Machine learning classifiers can detect memory reactivations during sleep.
- This approach could optimize therapeutic interventions without drugs.

## Abstract

Sleep engineering could be developed to provide a drug-free, non-invasive avenue to treat depression and post-traumatic stress disorder. Such an intervention would be greatly aided by the sophisticated detection of memory reactivations using machine learning classifiers.

Could sleep engineering be developed to provide a drug-free, non-invasive avenue to treat depression and post-traumatic stress disorder? This Perspective proposes using machine learning with EEG signals to develop and optimize this type of intervention.

## Linked entities

- **Diseases:** depression (MONDO:0002050), post-traumatic stress disorder (MONDO:0005146)

## Full-text entities

- **Diseases:** schizophrenia (MESH:D012559), psychiatric (MESH:D001523), trauma (MESH:D014947), PTSD (MESH:D013313), non-rapid eye movement (MESH:D020923), depression (MESH:D003866)
- **Chemicals:** norepinephrine (MESH:D009638), TMR (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12928472/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12928472/full.md

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Source: https://tomesphere.com/paper/PMC12928472