# Ten simple rules for coordinating a large digital health project: Perspectives from EU and implications for global contexts

## TL;DR

This paper provides ten practical rules for coordinating large digital health projects, based on experience from a European cancer care initiative.

## Contribution

Ten evidence-based coordination rules for international digital health projects, derived from a European multi-partner initiative.

## Key findings

- Balanced consortia and cultural alignment are critical for multi-partner digital health projects.
- Effective timeline management and regulatory compliance improve project success.
- Dissemination and exploitation strategies ensure long-term impact in global health initiatives.

## Abstract

Coordinating a large-scale digital health project requires a unique mix of scientific leadership, administrative skill, and human sensitivity. Drawing from our experience leading CAPABLE, a European Horizon 2020 project aimed at improving the quality of life of cancer patients through AI and telemedicine, we present ten practical rules for navigating the complex landscape of multi-partner biomedical research. These rules address challenges such as building balanced consortia, managing timelines and regulatory requirements, ensuring cultural alignment, and promoting long-term impact through dissemination and exploitation. The paper specifically addresses international research projects at the intersection of healthcare and IT and their peculiar challenges, typically connected to the interplay of different actors such as academics, healthcare personnel, and industry partners located in different countries, each from diverse backgrounds and different working practices. Our goal is to provide researchers and project coordinators with concrete guidance to increase the likelihood of success in future large digital health initiatives.