# Genomic Analysis of Doxycycline Resistance–Associated 16S rRNA Mutations in Treponema pallidum Subspecies pallidum

## TL;DR

This study identifies genomic mutations in Treponema pallidum linked to doxycycline resistance, providing a global baseline for tracking antibiotic resistance in syphilis.

## Contribution

The study provides the first global genomic baseline for doxycycline resistance in Treponema pallidum subspecies pallidum.

## Key findings

- Nine non-Canadian genomes showed variants associated with doxycycline resistance.
- Seventeen new Canadian T. pallidum genomes were analyzed for resistance mutations.
- Findings can help monitor antibiotic resistance in syphilis treatment.

## Abstract

We inspected 16S rRNA sequences of 784 publicly available Treponema pallidum subspecies pallidum genomes and 17 new T. pallidum subsp. pallidum genomes from Canada for putative mutations associated with doxycycline resistance. Variants were detected in 9 non-Canada genomes. These findings establish a global genomic baseline for monitoring doxycycline resistance in syphilis.