# Vaccine-Like African Swine Fever Virus Strain in Domestic Pigs, Thailand, 2024 **Authors:** Trong Tung Nguyen, Dhithya Venkateswaran, Anwesha Prakash, Quynh Anh Nguyen, Roypim Suntisukwattana, Anan Jongkaewwattana, Theeradej Thaweerattanasinp, Janya Saenboonrueng, Van Phan Le, Dachrit Nilubol PMC · DOI: 10.3201/eid3202.251245 · Emerging Infectious Diseases · 2026-02-01 ## TL;DR A vaccine-like strain of African swine fever virus was found in pigs in Thailand, causing chronic disease despite no vaccination. ## Contribution Identification of a vaccine-like strain with gene deletions causing chronic disease in non-vaccinated pigs. ## Key findings - A vaccine-like strain with 6 multigene family gene deletions was identified in non-vaccinated herds. - The strain was associated with chronic disease in pigs rather than acute disease. - This strain belongs to genotype II of African swine fever virus. ## Abstract African swine fever virus genotype II is endemic in Thailand, typically causing acute disease. We investigated a vaccine-like strain, characterized by 6 multigene family gene deletions, from nonvaccinated herds. We found this strain was associated with chronic disease in pigs. ## Linked entities - **Diseases:** African swine fever (MONDO:0025377) ## Full-text entities - **Genes:** STAT5A (signal transducer and activator of transcription 5A) [NCBI Gene 6776] {aka MGF, STAT5} - **Diseases:** ASF (MESH:D000357), joint swelling (MESH:D007592), respiratory disease (MESH:D012140), deaths (MESH:D003643), hemorrhagic disease (MESH:D006470), weight gain (MESH:D015430) - **Chemicals:** guanine (MESH:D006147), FR682468 (-) - **Species:** Homo sapiens (human, species) [taxon 9606], Escherichia coli (E. coli, species) [taxon 562], Sus scrofa (pig, species) [taxon 9823], Classical swine fever virus (no rank) [taxon 11096], African swine fever virus (no rank) [taxon 10497] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12928227/full.md ## Figures 2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12928227/full.md ## References 10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12928227/full.md --- Source: https://tomesphere.com/paper/PMC12928227