# Monkeypox Virus Antibodies in Healthy Persons after Vaccination with MVA-BN, United Kingdom

**Authors:** Victoria H. Sheridan, Craig W. Duffy, Jake Dunning, Lance Turtle, Julian A. Hiscox, Krishanthi S. Subramaniam

PMC · DOI: 10.3201/eid3202.251553 · Emerging Infectious Diseases · 2026-02-01

## TL;DR

This study shows that the MVA-BN vaccine can generate antibodies against two monkeypox virus clades in vaccinated individuals.

## Contribution

The study demonstrates cross-neutralizing antibody responses to monkeypox virus clade Ib following MVA-BN vaccination.

## Key findings

- A 2-dose MVA-BN regimen generates neutralizing antibodies for monkeypox virus clades Ib and IIb.
- Higher antibody responses were observed against clade IIb compared to clade Ib.

## Abstract

A 2-dose regimen of the vaccine modified vaccinia Ankara–Bavarian Nordic (MVA-BN) can generate neutralizing antibodies for monkeypox virus clades Ib and IIb. We observed higher response to clade IIb; that result provides evidence that MVA-BN vaccination can induce cross-neutralizing antibodies for monkeypox virus clade Ib as well as for clade IIb.

## Linked entities

- **Diseases:** monkeypox (MONDO:0002594)

## Full-text entities

- **Diseases:** psoriasis (MESH:D011565), asthma (MESH:D001249), multiple sclerosis (MESH:D009103), infections (MESH:D007239)
- **Chemicals:** MVA (MESH:C051113), mpox (MESH:C051836), MVA-BN (-)
- **Species:** Variola virus (smallpox virus, no rank) [taxon 10255], Cavia porcellus (domestic guinea pig, species) [taxon 10141], Monkeypox virus (no rank) [taxon 10244], mumps virus [taxon 1979165], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12928222/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12928222/full.md

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Source: https://tomesphere.com/paper/PMC12928222