# Temporal Clustering of Mycoplasma pneumoniae–Associated Encephalitis and Stroke, South Korea, 2024

**Authors:** Seung Ha Song, Dayun Kang, Ye Kyung Kim, Jaeso Cho, Hye Jin Kim, Woojoong Kim, Ki Wook Yun

PMC · DOI: 10.3201/eid3202.251296 · Emerging Infectious Diseases · 2026-02-01

## TL;DR

A cluster of pediatric encephalitis and stroke cases linked to a Mycoplasma pneumoniae outbreak in South Korea suggests new neurological risks post-pandemic.

## Contribution

Identifies a novel temporal clustering of neurological cases during a Mycoplasma pneumoniae epidemic in South Korea.

## Key findings

- Seventeen pediatric cases of encephalitis or stroke were temporally clustered during the 2023–2024 M. pneumoniae epidemic.
- Similar neurological patterns were not observed in previous M. pneumoniae seasons.
- Findings suggest postpandemic changes in clinical manifestations and highlight the need for neurological surveillance.

## Abstract

Seventeen pediatric encephalitis (n = 12) or stroke (n = 5) cases clustered temporally during the 2023–2024 Mycoplasma pneumoniae epidemic in South Korea; similar patterns had not been noted in previous seasons. Those findings might reflect postpandemic changes in clinical manifestation and underscore the need for neurologic surveillance during M. pneumoniae epidemics.

## Linked entities

- **Diseases:** encephalitis (MONDO:0019956), stroke (MONDO:0005098)

## Full-text entities

- **Diseases:** autoimmune (MESH:D001327), pneumonia (MESH:D011014), Stroke (MESH:D020521), focal deficits (MESH:D009461), CNS complication (MESH:D002493), infarctions (MESH:D007238), M. pneumoniae infection (MESH:C566367), infectious diseases (MESH:D003141), system complications (MESH:D009422), deaths (MESH:D003643), ischemic stroke (MESH:D002544), Bars (MESH:D001260), COVID-19 (MESH:D000086382), Encephalitis (MESH:D004660), Mycoplasma pneumoniae infections (MESH:D011019), cerebrovascular occlusion (MESH:D002561)
- **Chemicals:** macrolide (MESH:D018942)
- **Species:** Mycoplasmoides pneumoniae (Filterable agent of primary atypical pneumonia, species) [taxon 2104], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** A2063G

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12928221/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12928221/full.md

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Source: https://tomesphere.com/paper/PMC12928221