# Vesicular Disease Caused by Seneca Valley Virus in Pigs, England, 2022

**Authors:** Bryony Armson, Valérie Mioulet, Britta A. Wood, Antonello Di Nardo, Nick J. Knowles, Jemma Wadsworth, David J. Paton, Jozhel Baguisi, Harry Bull, Amy McCarron, Clare Browning, Ashley Gray, Tomasz Zaleski, Andrew E. Shaw, Anna B. Ludi, Mark Henstock, Hayley M. Hicks, Ginette Wilsden, Krupali Parekh, Julie Maryan, Sarah Belgrave, Noemi Polo, Simon Gubbins, Claire Colenutt, Melanie Nicholls, Emma Brown, Efthymia Nasou, Anca Drelciuc, Livio Pittalis, David Jorge, Caroline Wilson, Susana Taylor, Jose Bis, Charles Nfon, Susanna Williamson, Donald P. King

PMC · DOI: 10.3201/eid3202.251194 · Emerging Infectious Diseases · 2026-02-01

## TL;DR

A vesicular disease caused by Seneca Valley virus was identified in pigs in England in 2022, resembling more serious diseases like foot-and-mouth disease.

## Contribution

The study reports the first occurrence of Seneca Valley virus in England and identifies its genetic link to a U.S. strain.

## Key findings

- Vesicular disease in pigs was caused by Seneca Valley virus in five outdoor farms in England in 2022.
- The virus's genome showed a common ancestor with a strain circulating in the United States.

## Abstract

Vesicular disease caused by Seneca Valley virus infection occurred in pigs from 5 outdoor pig farms in England during June–September 2022. Clinical signs resembled notifiable vesicular diseases, such as foot-and-mouth disease. Full genome sequences shared a common ancestor with a virus circulating in the United States.

## Linked entities

- **Diseases:** foot-and-mouth disease (MONDO:0005765)
- **Species:** Sus scrofa (taxon 9823)

## Full-text entities

- **Diseases:** SVV disease (MESH:D014777), lameness (MESH:D007794), infected (MESH:D007239), erosions (MESH:D014077), foot-and-mouth disease (MESH:D005536), SVV (MESH:D003047), viremia (MESH:D014766), vesicular stomatitis virus (MESH:D054243), Vesicular Disease (MESH:D012872)
- **Species:** Swine vesicular disease virus (no rank) [taxon 12075], Suidae (boars, family) [taxon 9821], Sus scrofa (pig, species) [taxon 9823], Senecavirus A (no rank) [taxon 390157]
- **Cell lines:** SK6 — Sus scrofa (Pig), Spontaneously immortalized cell line (CVCL_D296)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12928217/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12928217/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12928217/full.md

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Source: https://tomesphere.com/paper/PMC12928217