# When Thyrotoxicosis Meets a Latent Plaque: Unmasking a Type I Myocardial Infarction

**Authors:** Joseph Muñoz, Damini Kashyap, Aleksandr Kouk, Thomas Greco, Joseph Maslak

PMC · DOI: 10.7759/cureus.102216 · Cureus · 2026-01-24

## TL;DR

A young man with no heart risk factors had a heart attack linked to thyrotoxicosis, highlighting the need to consider thyroid issues in such cases.

## Contribution

Highlights thyrotoxicosis as a rare but important cause of heart attacks in young, low-risk patients.

## Key findings

- A 36-year-old man with thyrotoxicosis experienced a type I myocardial infarction.
- Thyrotoxicosis should be considered in the differential diagnosis of ACS in young patients.
- Excess thyroid hormone may contribute to coronary artery stenosis and heart attacks.

## Abstract

Thyrotoxicosis is a rare but significant precipitant of acute coronary syndrome (ACS), especially in young individuals without traditional cardiovascular risk factors. We present the case of a 36-year-old male with no past medical history who arrived with substernal chest pain, elevated troponins, and sinus rhythm without ST changes on ECG. Thyroid ultrasound revealed a large goiter, and labs confirmed severe thyrotoxicosis. Coronary angiography showed 85% stenosis of the proximal-to-mid left anterior descending artery, managed successfully with stent placement. This case demonstrates how an excess of thyroid hormone may contribute to the development of type I myocardial infarction. Thyrotoxicosis should be included in the differential diagnosis of ACS in young patients without traditional risk profiles to ensure timely diagnosis and targeted therapy.

## Linked entities

- **Diseases:** thyrotoxicosis (MONDO:0010138), acute coronary syndrome (MONDO:0005542), myocardial infarction (MONDO:0005068)

## Full-text entities

- **Genes:** REN (renin) [NCBI Gene 5972] {aka ADTKD4, HNFJ2, RTD}, TPO (thyroid peroxidase) [NCBI Gene 7173] {aka MSA, TDH2A, TPX}, TG (thyroglobulin) [NCBI Gene 7038] {aka AITD3, TGN}
- **Diseases:** Graves disease (MESH:D006111), UA (MESH:D000789), coronary stenosis (MESH:D023921), vasospasm (MESH:D020301), sepsis (MESH:D018805), stenosis (MESH:D003251), ischemia (MESH:D007511), goiter (MESH:D006042), chest pain (MESH:D002637), myocardial injury (MESH:D009202), Thyrotoxicosis (MESH:C566386), coronary artery disease (MESH:D003324), hyperthyroid (MESH:D006980), LAD stenosis (MESH:D000094629), neoplastic thyroid disease (MESH:D013959), NSTEMI (MESH:D000072657), arrhythmias (MESH:D001145), depression (MESH:D003866), coronary vasospasm (MESH:D003329), weight loss (MESH:D015431), Type I Myocardial Infarction (MESH:D009203), endothelial dysfunction (MESH:D014652), ischemic (MESH:D002545), diabetes mellitus (MESH:D003920), vessel disease (MESH:C536223), left ventricular hypertrophy (MESH:D017379), hypertension (MESH:D006973), ACS (MESH:D054058), atherosclerosis (MESH:D050197), coronary pathology (MESH:D003327), toxic multinodular goiter (MESH:C564546), anemia (MESH:D000740), inflammation (MESH:D007249), thyrotoxic (MESH:D013958), hyperlipidemia (MESH:D006949), platelet aggregation (MESH:D001791), thrombus (MESH:D013927)
- **Chemicals:** isosorbide mononitrate (MESH:C030397), nitric oxide (MESH:D009569), metoprolol tartrate (MESH:D008790), T3 (MESH:D014284), lipid (MESH:D008055), aspirin (MESH:D001241), catecholamine (MESH:D002395), nitroglycerin (MESH:D005996), atorvastatin (MESH:D000069059), oxygen (MESH:D010100), T4 (MESH:D013974), T3/T4 (-), prasugrel (MESH:D000068799)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12928174/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12928174/full.md

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Source: https://tomesphere.com/paper/PMC12928174