# Amitriptyline Induced Life‐Threatening Steven–Johnson Syndrome: Case Report

## TL;DR

This case report describes a rare instance of life-threatening Stevens–Johnson syndrome caused by amitriptyline, a drug not previously linked to this condition.

## Contribution

The novelty is the first reported case of Stevens–Johnson syndrome caused by amitriptyline.

## Key findings

- Amitriptyline can cause life-threatening Stevens–Johnson syndrome.
- This case adds to the list of drugs associated with the syndrome.

## Abstract

Stevens–Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine, and carbamazepine are commonly implicated. Stevens–Johnson syndrome due to amitriptyline combination has not been reported in the literature before.