# Cover Image

**Authors:** Brian H. Im, Kevin K. Zarrabi, Aaron R. Hochberg, Mihir S. Shah, James R. Mark, Joseph K. Izes, Patrick T. Gomella, Costas D. Lallas, Leonard G. Gomella, Adam R. Metwalli

PMC · DOI: 10.1002/cam4.71632 · Cancer Medicine · 2026-02-23

## TL;DR

This paper investigates how bone-remodeling therapy affects survival and pain in kidney cancer patients with bone metastases.

## Contribution

The study provides new insights into the effectiveness of bone-remodeling therapy in a global multicenter setting.

## Key findings

- Bone-remodeling therapy was associated with improved survival outcomes.
- The therapy showed potential in reducing skeletal-related events and pain.
- Findings were derived from a large global health research network.

## Abstract

The cover image is based on the article The Effects of Bone‐Remodeling Therapy on Survival, Pain, and Skeletal Related Events in the Setting of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From a Large Global Health Research Network (TriNetX) by Brian H. Im et al., https://doi.org/10.1002/cam4.71133.

## Linked entities

- **Diseases:** Renal Cell Carcinoma (MONDO:0005086)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12928059/full.md

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Source: https://tomesphere.com/paper/PMC12928059