# Peters Anomaly in a Miniature Schnauzer Documented by Spectral‐Domain Optical Coherence Tomography: A Case Report

**Authors:** Yukihiro Miwa, Deokho Lee, Yuri Inukai

PMC · DOI: 10.1002/ccr3.72136 · Clinical Case Reports · 2026-02-22

## TL;DR

A 10-month-old dog had Peters anomaly in its eye, confirmed using advanced imaging for the first time in a canine case.

## Contribution

First documentation of Peters anomaly in a dog using spectral-domain optical coherence tomography.

## Key findings

- SD-OCT revealed focal absence of Descemet's membrane and corneal endothelium defect.
- Iridocorneal adhesions were observed extending from the iris to the cornea.
- This case confirms Peters anomaly in a Miniature Schnauzer using non-invasive imaging.

## Abstract

A 10‐month‐old intact male Miniature Schnauzer was presented for evaluation of a unilateral corneal opacity in the right eye. Ophthalmic examination revealed a broad paraxial corneal opacity involving the posterior stroma to the Descemet's membrane, with multiple strands of tissue extending from the iris collarette to the posterior cornea. Spectral‐domain optical coherence tomography (SD‐OCT) revealed focal absence of the Descemet's membrane and a defect in the corneal endothelium in the affected area. Based on the clinical and imaging findings, the case was diagnosed as Peters anomaly. To the authors' knowledge, this is the first report of Peters anomaly in a dog documented by SD‐OCT.

This case highlights Peters anomaly in a dog, documented by spectral‐domain OCT, demonstrating focal absence of Descemet's membrane and iridocorneal adhesions. OCT provides in vivo confirmation of congenital anterior segment dysgenesis and is a valuable non‐invasive tool for veterinary diagnosis and education.

## Linked entities

- **Diseases:** Peters anomaly (MONDO:0011414)

## Full-text entities

- **Genes:** FOXC1 (forkhead box C1) [NCBI Gene 2296] {aka ARA, ASGD3, FKHL7, FREAC-3, FREAC3, IGDA}, PAX6 (paired box 6) [NCBI Gene 5080] {aka AN, AN1, AN2, ASGD5, D11S812E, FVH1}, COL6A3 (collagen type VI alpha 3 chain) [NCBI Gene 1293] {aka BTHLM1, BTHLM1C, DYT27, UCMD1, UCMD1C}, SOX2 (SRY-box transcription factor 2) [NCBI Gene 6657] {aka ANOP3, MCOPS3}, PITX2 (paired like homeodomain 2) [NCBI Gene 5308] {aka ARP1, ASGD4, Brx1, IDG2, IGDS, IGDS2}, FOXE3 (forkhead box E3) [NCBI Gene 2301] {aka AAT11, ASGD2, CATC3, CTRCT34, FKHL12, FREAC8}, CYP1B1 (cytochrome P450 family 1 subfamily B member 1) [NCBI Gene 1545] {aka ASGD6, CP1B, CYPIB1, GLC3A, P4501B1}, PITX3 (paired like homeodomain 3) [NCBI Gene 5309] {aka ASGD1, ASMD, ASOD, CTPP4, CTRCT11}
- **Diseases:** OS (MESH:C567932), retinal detachment (MESH:D012163), Peters Anomaly (MESH:C537884), corneal opacity (MESH:D003318), congenital anterior segment dysgenesis (MESH:C537775), lens abnormalities (MESH:D007905), ocular pain (MESH:D058447), congenital malformation of (OMIM:163000), developmental anomalies (MESH:C566440), corneal decompensation (MESH:D006333), OD (OMIM:165800), cataractous (MESH:D002386), Descemet's membrane (MESH:D015433), glaucoma (MESH:D005901), corneal endothelial defects (MESH:C536439)
- **Species:** Canis lupus familiaris (dog, subspecies) [taxon 9615], Felis catus (cat, species) [taxon 9685], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12928040/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12928040/full.md

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Source: https://tomesphere.com/paper/PMC12928040