# Hepatoid Adenocarcinoma of the Lung: A Case Report on a Rare Medical Condition

**Authors:** Fawad Talat, Abdul Subhan Talpur, Behrawar Ahmad, Marwa Mahjoub, Fnu Raheela, Adarsh Srinivas Ramesh, Madhuri Yalamanchili

PMC · DOI: 10.7759/cureus.102211 · Cureus · 2026-01-24

## TL;DR

This case report describes a rare lung cancer in an 82-year-old man that mimicked liver cancer and had a poor prognosis.

## Contribution

The novelty lies in documenting a rare hepatoid adenocarcinoma of the lung case with its clinical presentation and outcome.

## Key findings

- The patient was initially suspected to have metastatic HCC but was diagnosed with hepatoid adenocarcinoma of the lung.
- The patient received immunotherapy and chemotherapy but died within six months, indicating the aggressive nature of the disease.

## Abstract

We describe a case of an 82-year-old man who initially presented with back pain in the thoracic region and, on imaging, was found to have a right lower lobe lung nodule and a soft tissue mass eroding the posterior aspect of the right-sided ninth rib. Biopsy of this soft-tissue mass initially raised concern for metastatic HCC, but the patient was later found to have hepatoid adenocarcinoma of the lung. The patient was started on immunotherapy and a chemotherapy regimen, but unfortunately died within six months of diagnosis, highlighting the aggressive nature and course of the disease.

## Full-text entities

- **Genes:** AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, NAPSA (napsin A aspartic peptidase) [NCBI Gene 9476] {aka KAP, Kdap, NAP1, NAPA, NR1H2-AS1, SNAPA}, KRT19 (keratin 19) [NCBI Gene 3880] {aka CK19, K19, K1CS}, KRT18 (keratin 18) [NCBI Gene 3875] {aka CK-18, CYK18, K18}, KRT8 (keratin 8) [NCBI Gene 3856] {aka CARD2, CK-8, CK8, CYK8, K2C8, K8}, ARG1 (arginase 1) [NCBI Gene 383], EPCAM (epithelial cell adhesion molecule) [NCBI Gene 4072] {aka Ber-Ep4, BerEp4, DIAR5, EGP-2, EGP314, EGP40}
- **Diseases:** hypothyroidism (MESH:D007037), back pain (MESH:D001416), abdominal/pelvic lesions (MESH:D000008), hepatic and liver masses (MESH:D008107), metastasis (MESH:D009362), chronic kidney disease (MESH:D051436), neuroendocrine carcinoma (MESH:D018278), hepatoid carcinoma of the lung (MESH:D008175), SOB (MESH:D004417), acinar or papillary adenocarcinoma (MESH:D000231), HAC (MESH:D000230), cancer (MESH:D009369), atrial fibrillation (MESH:D001281), chest/lung lesion (MESH:D008171), hepatic lesion (MESH:D056486), Medical (MESH:D000069279), pneumonitis (MESH:D011014), mediastinal lymphadenopathy (MESH:D008477), coronary artery disease (MESH:D003324), bacterial pneumonia (MESH:D018410), lymphadenopathy (MESH:D008206), HAC of the lung (MESH:D000077192), essential hypertension (MESH:D000075222), rib lesion (MESH:C537613), HCC (MESH:D006528), signet-ring cells (MESH:D018279)
- **Chemicals:** pemetrexed (MESH:D000068437), platinum (MESH:D010984), paclitaxel (MESH:D017239), pembrolizumab (MESH:C582435)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12927955/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12927955/full.md

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Source: https://tomesphere.com/paper/PMC12927955