# Visualized analysis of core themes and emerging frontiers in global chikungunya virus studies

**Authors:** Jing Tian, Yonggang Li, Yuanlong Zhao, Xiaoli Tao

PMC · DOI: 10.3389/fmicb.2025.1707833 · Frontiers in Microbiology · 2026-02-09

## TL;DR

This study maps global research trends in chikungunya virus to identify key themes and future directions for controlling outbreaks.

## Contribution

A bibliometric analysis of CHIKV research from 2015–2024 reveals emerging trends and key contributors using visualization tools.

## Key findings

- The U.S., Brazil, and India led in CHIKV research output, with French institutions showing strong performance.
- Phylogenetic analysis, epidemiology, and vaccine development are current research hotspots.
- Future research should focus on viral evolution, immune interactions, and global risk prediction models.

## Abstract

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has caused multiple outbreaks worldwide in recent years, resulting in millions of infections and severe complications such as chronic arthritis, posing an ongoing threat to global public health.

This study employs bibliometric methods to systematically analyze the core themes, development trends, and research frontiers in CHIKV research, aiming to provide a scientific basis for research planning and prevention strategies.

Based on the Web of Science Core Collection database, a total of 3,709 relevant publications from 2015 to 2024 were included. Visualization tools such as VOSviewer and CiteSpace were used to analyze countries/regions, institutions, authors, journals, keywords, and co-citation networks.

The results indicated that the United States, Brazil, and India were the most productive countries, while French institutions stood out in research output. Scott C. Weaver was identified as the most prolific author. Journals including PLOS Neglected Tropical Diseases, Viruses, and the Journal of Virology demonstrated significant influence in this field. Co-citation and keyword cluster analyses revealed that phylogenetic analysis, epidemiology, pathogenesis, drug therapy, and vaccine development represent current research hotspots. International collaboration plays a key role in promoting global phylogenetic studies and data integration.

CHIKV research is expanding from epidemiology to pathogenic mechanisms, targeted therapies, and public health prevention strategies. Future efforts should focus on viral evolution mechanisms, host immune interactions, multi platform vaccine development, and the construction of global risk prediction models to address the persistent challenges posed by CHIKV outbreaks.

## Full-text entities

- **Genes:** MXRA8 (matrix remodeling associated 8) [NCBI Gene 54587] {aka ASP3}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, SH2D3A (SH2 domain containing 3A) [NCBI Gene 10045] {aka NSP1}, ERVK-6 (endogenous retrovirus group K member 6, envelope) [NCBI Gene 64006] {aka ERVK6, HERV-K(C7), HERV-K108, K-Rev, c-orf, cORF}, FHL1 (four and a half LIM domains 1) [NCBI Gene 2273] {aka FCMSU, FHL-1, FHL1A, FHL1B, FLH1A, KYOT}, DNAH8 (dynein axonemal heavy chain 8) [NCBI Gene 1769] {aka ATPase, SPGF46, hdhc9}
- **Diseases:** acute encephalitis syndrome (MESH:D000071072), Dengue infection (MESH:D003715), CHIKV infection (MESH:D065632), viremia (MESH:D014766), PLOS Neglected Tropical Diseases (MESH:D058069), microcephaly (MESH:D008831), Zika (MESH:D000071243), viral infectious diseases (MESH:D018792), Mosquito-Borne Disease (MESH:D000079426), fever (MESH:D005334), arthropathic damage (MESH:D020263), Infectious Diseases (MESH:D003141), co-infections (MESH:D060085), inflammatory (MESH:D007249), arthritis (MESH:D001168), arboviral diseases (MESH:D004671), infection (MESH:D007239), foot swelling (MESH:D005530), COVID-19 (MESH:D000086382), cytotoxicity (MESH:D064420), joint damage (MESH:D007592), arthralgia (MESH:D018771), chikungunya and O'nyong nyong virus infections (MESH:D018354), Tropical Diseases (MESH:D015493), rheumatic diseases (MESH:D012216)
- **Chemicals:** apigenin (MESH:D047310), chloroquine (MESH:D002738), FGDF (-), GAGs (MESH:D006025), chrysin (MESH:C043561)
- **Species:** Dengue virus (no rank) [taxon 12637], Alphavirus (arboviruses group A, genus) [taxon 11019], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Chikungunya virus (no rank) [taxon 37124], Aedes aegypti (yellow fever mosquito, species) [taxon 7159], Aedes albopictus (Asian tiger mosquito, species) [taxon 7160], Aedes (subgenus) [taxon 149531], Zika virus (no rank) [taxon 64320], Dengue virus group (clade) [taxon 11052], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** K211E, V264A, A226V

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12927478/full.md

## References

75 references — full list in the complete paper: https://tomesphere.com/paper/PMC12927478/full.md

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Source: https://tomesphere.com/paper/PMC12927478