# Role of insulin-regulated aminopeptidase as potential biomarker in insulin resistant polycystic ovary syndrome patients

## TL;DR

This study found that lower levels of insulin-regulated aminopeptidase in women with polycystic ovary syndrome may indicate insulin resistance, suggesting it could be a useful biomarker.

## Contribution

The study identifies insulin-regulated aminopeptidase as a potential biomarker for insulin resistance in polycystic ovary syndrome.

## Key findings

- Serum insulin-regulated aminopeptidase levels were significantly lower in polycystic ovary syndrome patients compared to healthy controls.
- Insulin-regulated aminopeptidase levels were even lower in insulin-resistant polycystic ovary syndrome patients.
- The levels showed a negative correlation with markers of insulin resistance like fasting blood glucose and HOMA-IR.

## Abstract

To measure serum insulin-regulated aminopeptidase levels in women diagnosed
with polycystic ovary syndrome and to investigate their potential
contribution of these levels to the development of insulin resistance, which
plays a central role in the pathophysiology of polycystic ovary
syndrome.

The study group, recruited between May and December 2021, consisted of 40
patients diagnosed with polycystic ovary syndrome and 40 age-matched healthy
controls. Serum insulin-regulated aminopeptidase levels were compared
between the groups using the ELISA method.

Serum insulin-regulated aminopeptidase levels were significantly lower in the
polycystic ovary syndrome group compared with the control group (p <
0.001). Subparameter assessments revealed that insulin-regulated
aminopeptidase levels were even lower in insulin-resistant polycystic ovary
syndrome patients (p = 0.001). Moreover, insulin-regulated aminopeptidase
levels demonstrated a statistically significant negative correlation with
fasting blood glucose, insulin, glycated hemoglobin, and HOMA-IR values.

Serum insulin-regulated aminopeptidase levels were found to be lower in women
with polycystic ovary syndrome than those in healthy controls. Furthermore,
these levels appear to reflect insulin resistance, a key factor in the
pathogenesis of polycystic ovary syndrome. Overall, these findings suggest
that insulin-regulated aminopeptidase may serve as a potential biomarker for
the identifification of insulin resistance in women with polycystic ovary
syndrome.