# Large Vulvar Fibroepithelial Stromal Polyp With Superficial Vascular Thrombosis: A Case Report

**Authors:** Efthymia Thanasa, Emmanouil M Xydias, Anna Thanasa, Vasiliki Koutsia, Dimitra Koutsonikola, Konstantinos Zachos, Georgios Toulios, Apostolos C Ziogas, Ioannis Thanasas

PMC · DOI: 10.7759/cureus.102188 · Cureus · 2026-01-24

## TL;DR

A postmenopausal woman had a rare vulvar polyp with blood clots, diagnosed and treated successfully with surgery.

## Contribution

This case report documents a rare vulvar fibroepithelial stromal polyp with superficial vascular thrombosis in a postmenopausal patient.

## Key findings

- A vulvar fibroepithelial stromal polyp with superficial vascular thrombosis was confirmed via histopathology.
- The patient had no history of hormone replacement therapy or tamoxifen use.
- Surgical excision led to successful treatment with no recurrence after six months.

## Abstract

The present case report concerns a postmenopausal patient who presented to the gynecological outpatient clinic of the hospital with a two-year history of a pedunculated mass located in the vulvar region, which had gradually increased in size. During the preceding six months, the patient reported discomfort and difficulty during ambulation and sitting, as well as intermittent mild vulvar pain not associated with any local trauma. Clinical examination revealed a pedunculated vulvar lesion with a maximum diameter of approximately 45 mm, oval-shaped, semi-firm in consistency, and non-tender on palpation. Based on the clinical findings, a strong presumptive diagnosis of a vulvar fibroepithelial stromal polyp was made, and surgical excision of the lesion was decided. Histopathological examination of the surgical specimen confirmed the diagnosis of a vulvar fibroepithelial stromal polyp with superficial dermal vascular thrombosis. The postoperative course was uneventful. No evidence of disease recurrence was observed six months following surgery. The patient remains under regular follow-up with annual clinical evaluations to date. This case report highlights the unusual occurrence of a vulvar fibroepithelial stromal polyp with superficial vascular thrombosis in a postmenopausal patient without a history of hormone replacement therapy or tamoxifen use. Additionally, the main risk factors are reviewed, and the contemporary diagnostic approach to this rare pathological entity is discussed, emphasizing the pivotal role of surgical management and the necessity of distinguishing it from malignant vulvar conditions.

## Linked entities

- **Diseases:** vulvar fibroepithelial stromal polyp (MONDO:0006620)

## Full-text entities

- **Genes:** VIM (vimentin) [NCBI Gene 7431], MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}, CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}, DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}
- **Diseases:** benign tumors (MESH:D009369), diabetes (MESH:D003920), cardiovascular diseases (MESH:D002318), Vulvar (MESH:D014845), skin lesion (MESH:D012871), cervical cancer (MESH:D002583), hypothyroidism (MESH:D007037), hypertension (MESH:D006973), Pain (MESH:D010146), inguinal lymphadenopathy (MESH:D006552), Thrombosis (MESH:D013927), inflammation (MESH:D007249), trauma (MESH:D014947), angiofibroma (MESH:D018322), neurofibromas (MESH:D009455), necrotic (MESH:D009336), sarcomas (MESH:D012509), erythema (MESH:D004890), thrombotic lesion (MESH:D020767), bleeding (MESH:D006470), obesity (MESH:D009765), polyp (MESH:D011127), Botryoid embryonal rhabdomyosarcoma (MESH:D018233), angiomyxoma (MESH:D009232), leiomyomas (MESH:D007889), vulvar malignancies (MESH:D014846), Fibroepithelial Stromal Polyp (MESH:D018225)
- **Chemicals:** tamoxifen (MESH:D013629), hematoxylin (MESH:D006416), glucose (MESH:D005947), Glu (MESH:D018698), eosin (MESH:D004801)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12926783/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12926783/full.md

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Source: https://tomesphere.com/paper/PMC12926783