# Pulmonary Pneumocytoma: A Benign Rarity Behind a Suspicious Nodule

**Authors:** Krin Suhr, Florencia Belen Basile, Adolfo Rosales, Moises Rosenberg, Emiliano Navarro

PMC · DOI: 10.7759/cureus.102132 · Cureus · 2026-01-23

## TL;DR

Pulmonary pneumocytoma is a rare benign lung tumor that can be mistaken for cancer, requiring careful diagnosis to avoid unnecessary treatment.

## Contribution

This paper presents a case emphasizing the importance of considering pneumocytoma in the differential diagnosis of lung nodules.

## Key findings

- Pneumocytoma was confirmed in a 40-year-old female via surgical resection and histopathology.
- The case underscores the need for multidisciplinary evaluation to prevent overtreatment.
- Pneumocytoma should be considered in the differential diagnosis of solitary pulmonary nodules in middle-aged women.

## Abstract

Pulmonary pneumocytoma is a rare benign tumor most often detected incidentally as a solitary pulmonary nodule. Although its radiological appearance is nonspecific, its histological complexity can mimic several malignant neoplasms, leading to potential overtreatment. We report a case of a 40-year-old female with a suspicious pulmonary lesion discovered during the evaluation of an unrelated oropharyngeal carcinoma. Surgical resection and histopathological analysis confirmed the diagnosis of pneumocytoma. This case highlights the importance of considering pneumocytoma in the differential diagnosis of solitary pulmonary nodules, particularly in middle-aged female patients. Early multidisciplinary evaluation is essential to avoid unnecessary radical treatment.

## Linked entities

- **Diseases:** oropharyngeal carcinoma (MONDO:0004608), pneumocytoma (MONDO:0006280)

## Full-text entities

- **Genes:** CHGA (chromogranin A) [NCBI Gene 1113] {aka CGA, PHE5, PHES}, CD34 (CD34 molecule) [NCBI Gene 947], NKX2-1 (NK2 homeobox 1) [NCBI Gene 7080] {aka BCH, BHC, NK-2, NKX2.1, NKX2A, NMTC1}, ERG (ETS transcription factor ERG) [NCBI Gene 2078] {aka LMPHM14, erg-3, p55}, TTF1 (transcription termination factor 1) [NCBI Gene 7270] {aka TTF-1, TTF-I}, CD68 (CD68 molecule) [NCBI Gene 968] {aka GP110, LAMP4, SCARD1}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, SYP (synaptophysin) [NCBI Gene 6855] {aka MRX96, MRXSYP, XLID96}, PECAM1 (platelet and endothelial cell adhesion molecule 1) [NCBI Gene 5175] {aka CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM}, NAPSA (napsin A aspartic peptidase) [NCBI Gene 9476] {aka KAP, Kdap, NAP1, NAPA, NR1H2-AS1, SNAPA}, NCAM1 (neural cell adhesion molecule 1) [NCBI Gene 4684] {aka CD56, MSK39, NCAM}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}
- **Diseases:** pulmonary hypertension (MESH:D006976), adenitis (MESH:D008199), head and neck squamous cell carcinoma (MESH:D000077195), squamous cell carcinoma (MESH:D002294), angiosarcoma (MESH:D006394), pulmonary mass (MESH:C536030), hemoptysis (MESH:D006469), chest pain (MESH:D002637), carcinoid tumor (MESH:D002276), papillary adenoma (MESH:D000236), mesothelioma (MESH:D008654), bleeding (MESH:D006470), lung adenocarcinoma (MESH:D000077192), lymphadenopathy (MESH:D008206), pulmonary nodule (MESH:D055613), epithelial tumors (MESH:D002277), cough (MESH:D003371), vascular neoplasms (MESH:D019043), oropharyngeal carcinoma (MESH:D009959), vascular injury (MESH:D057772), Pulmonary Pneumocytoma (MESH:D008171), Tumor (MESH:D009369), adenocarcinoma (MESH:D000230), benign lung tumor (MESH:D008175), dyspnea (MESH:D004417), endometriosis (MESH:D004715), sclerosing hemangioma (MESH:D018219), pulmonary metastasis (MESH:D009362), dysphagia (MESH:D003680), atelectasis (MESH:D001261)
- **Chemicals:** FDG (MESH:D019788)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12926682/full.md

## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC12926682/full.md

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Source: https://tomesphere.com/paper/PMC12926682