# Slot-Based Antimicrobial Low-Cost Non-surgical Periodontal Therapy in the Management of Periodontitis: A Case Series and Narrative Review

**Authors:** Rohit Mishra, Varsha Choubey, Elashri Chatterjee, Sukirti Singh, Priyanshi Wasalya, Dhairya Jain, Shalini Mishra, Anshul Gulati, Paramjeet K Chhabra, Sheewali Saggar, Nikita Saini

PMC · DOI: 10.7759/cureus.102194 · Cureus · 2026-01-24

## TL;DR

This paper explores a low-cost, antimicrobial-based periodontal therapy as an effective alternative to traditional treatments for periodontitis.

## Contribution

The paper introduces slot-based therapy as a novel, cost-effective, antimicrobial adjunct to non-surgical periodontal treatment.

## Key findings

- Slot-based therapy reduced gingival inflammation and improved periodontal health in three patients.
- Adjunctive antimicrobial measures were safely and effectively integrated with mechanical debridement.
- Outcomes support slot therapy as a viable alternative in resource-limited settings.

## Abstract

Periodontitis is a chronic infectious and inflammatory disease characterized by progressive destruction of the periodontal ligament and alveolar bone. While scaling and root planing (SRP) remains the cornerstone of non-surgical periodontal therapy, mechanical debridement alone may be inadequate in cases with deep periodontal pockets and persistent microbial reservoirs. In the context of periodontitis, “slot-based therapy” refers to a comprehensive anti-infective treatment strategy based on pathogen-directed antimicrobial principles and low-cost periodontal care concepts, combining mechanical debridement with adjunctive antimicrobial measures in a simplified, cost-effective, and evidence-based approach, particularly suited to resource-limited clinical settings.

This article presents a case series of three patients with localized and generalized periodontitis who were managed using non-surgical slot therapy protocols. All patients exhibited varying degrees of gingival inflammation, plaque accumulation, and compromised periodontal health at baseline. Treatment involved ultrasonic SRP supplemented with adjunctive antiseptic-based antimicrobial strategies, including povidone-iodine subgingival irrigation and dilute sodium hypochlorite rinses for maintenance, with systemic antimicrobials prescribed selectively based on clinical indication. Clinical follow-up demonstrated a consistent reduction in gingival inflammation, improved gingival contour, and enhanced periodontal health across all three cases. No adverse effects were observed during the treatment or follow-up periods. The outcomes observed in this case series support the clinical utility of slot therapy as a pragmatic adjunct to conventional non-surgical periodontal treatment, offering a viable alternative to technology-dependent modalities while achieving meaningful clinical improvement.

## Linked entities

- **Chemicals:** povidone-iodine (PubChem CID 410087), sodium hypochlorite (PubChem CID 23665760)
- **Diseases:** periodontitis (MONDO:0005076)

## Full-text entities

- **Diseases:** diabetes mellitus (MESH:D003920), dysbiosis (MESH:D064806), chronic periodontitis (MESH:D055113), calculus (MESH:D002137), infective (MESH:D007239), cardiovascular disease (MESH:D002318), edema (MESH:D004487), alveolar bone destruction (MESH:D016301), gingival erythema (MESH:D005891), taste disturbance (MESH:D013651), tooth loss (MESH:D016388), tooth staining (MESH:D019339), Periodontitis (MESH:D010518), gingival inflammation (MESH:D007249), erythema (MESH:D004890), Periodontal disease (MESH:D010510), infectious (MESH:D003141), periodontal attachment loss (MESH:D017622), bleeding (MESH:D006470)
- **Chemicals:** sodium hypochlorite (MESH:D012973), metronidazole (MESH:D008795), ciprofloxacin (MESH:D002939), hexetidine (MESH:D006590), SRP (-), hydrogen peroxide (MESH:D006861), Chlorhexidine (MESH:D002710), amoxicillin (MESH:D000658), povidone-iodine (MESH:D011206), quaternary ammonium compounds (MESH:D000644), valacyclovir (MESH:D000077483)
- **Species:** Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], human gammaherpesvirus 4 (Epstein Barr virus, no rank) [taxon 10376], Homo sapiens (human, species) [taxon 9606], Porphyromonas gingivalis (species) [taxon 837], Aggregatibacter actinomycetemcomitans (species) [taxon 714], Human betaherpesvirus 5 (no rank) [taxon 10359]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12926676/full.md

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12926676/full.md

## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC12926676/full.md

---
Source: https://tomesphere.com/paper/PMC12926676