# β-amyloid and β-amyloid precursor protein synthesis and processing: effects of exercise and exercise-related injury

## TL;DR

This paper explores how exercise and exercise-related injuries might influence the processing of β-amyloid precursor protein, which is linked to Alzheimer's disease.

## Contribution

The study investigates the impact of exercise on APP processing and its changes in injury-related conditions, offering new insights into Alzheimer's prevention.

## Key findings

- Exercise may influence β-amyloid precursor protein processing and assembly.
- Exercise-related injuries could alter APP processing mechanisms.
- Future research directions are proposed to prevent adverse outcomes from these injuries.

## Abstract

During the processing and assembly of β-amyloid precursor protein (APP), the amyloidogenic pathway represents a crucial component of Alzheimer’s disease (AD) pathogenesis. The non-amyloidogenic pathway does not generate toxic Aβ. For a long time, research has delved deeply into both pathways, elucidating numerous important details and mechanisms within these processes. Scientists and clinicians have sought to design effective therapeutic interventions based on these mechanisms. However, this endeavor has encountered numerous setbacks, resulting in no currently available drugs capable of reversing AD progression. Regarding APP processing and assembly, we are curious whether daily activities influence these processes. We focus on exercise as a daily activity, systematically exploring whether it affects APP processing and assembly and the underlying mechanisms. Furthermore, we examine alterations in APP processing and assembly in exercise-related injury disorders, summarizing and analyzing existing research. We discuss promising future research directions, aiming to contribute to preventing adverse outcomes following exercise-related injuries.