# Case Report: Ultrasound-guided thrombin injection for the treatment of radial artery pseudoaneurysm after percutaneous coronary intervention

**Authors:** Xiaoyan Li, Guoqing Qi, Liye Wei

PMC · DOI: 10.3389/fcvm.2026.1753285 · Frontiers in Cardiovascular Medicine · 2026-02-09

## TL;DR

This case report shows that injecting thrombin under ultrasound guidance is an effective and minimally invasive treatment for radial artery pseudoaneurysm after heart procedures.

## Contribution

The report highlights the successful use of ultrasound-guided thrombin injection as a novel first-line treatment for radial artery pseudoaneurysm.

## Key findings

- Ultrasound-guided thrombin injection led to complete thrombosis within 30 seconds.
- The treatment resulted in sustained occlusion confirmed at 24-hour follow-up.
- UGTI is a safe and effective alternative to surgery for radial artery pseudoaneurysm.

## Abstract

Radial artery pseudoaneurysm (RAP) is an uncommon but significant complication after transradial coronary procedures. This case demonstrates the efficacy of ultrasound-guided thrombin injection (UGTI) as a minimally invasive treatment.

A 65-year-old Chinese male developed a RAP two days after percutaneous coronary intervention. Diagnosis was confirmed by Doppler ultrasound. UGTI was performed, injecting 1.5 mL of thrombin. Complete thrombosis occurred within 30 s, with sustained occlusion confirmed at 24-hour follow-up.

UGTI is a highly effective and safe first-line treatment for iatrogenic RAP, enabling rapid resolution and avoiding the need for surgery. It represents a superior minimally invasive strategy for managing this vascular complication.

## Full-text entities

- **Genes:** F2 (coagulation factor II, thrombin) [NCBI Gene 2147] {aka PT, RPRGL2, THPH1}
- **Diseases:** hypertension (MESH:D006973), radial artery occlusion (MESH:D001157), atherosclerosis (MESH:D050197), thrombosis (MESH:D013927), unstable angina (MESH:D000789), neurological or vascular complications (MESH:D020785), thromboembolism (MESH:D013923), tenderness (MESH:D063806), coronary artery disease (MESH:D003324), allergic reactions (MESH:D004342), embolism (MESH:D004617), swelling (MESH:D004487), aneurysm (MESH:D000783), RAP (MESH:D017541), rupture (MESH:D012421), dyslipidemia (MESH:D050171), nerve compression (MESH:D009408), ischemia (MESH:D007511), triple-vessel disease (MESH:C536008), vascular complication (MESH:D003925), UGTI (MESH:D019851), bleeding (MESH:D006470)
- **Chemicals:** UGTI (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12926404/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12926404/full.md

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Source: https://tomesphere.com/paper/PMC12926404