# Are SEP-1 and blood culture stewardship at odds? Retrospective review of SEP-1 failures pre- and during a blood culture bottle shortage

**Authors:** Jonathan H. Ryder, Kelly A. Cawcutt, Cynthia Japp, Trevor C. Van Schooneveld

PMC · DOI: 10.1017/ice.2025.10317 · Infection Control and Hospital Epidemiology · 2025-12-12

## TL;DR

This study examines whether blood culture stewardship during a shortage conflicts with SEP-1 requirements, finding that many cultures could be safely avoided without harming patients.

## Contribution

The study provides evidence that blood culture stewardship can safely reduce unnecessary testing during shortages without compromising patient outcomes.

## Key findings

- SEP-1 compliance declined during the blood culture bottle shortage due to reduced utilization.
- Most cases where blood cultures were not obtained did not result in patient harm.
- Enhanced stewardship practices allowed for safe avoidance of unnecessary blood cultures.

## Abstract

Timely blood cultures (BCx) are required by SEP-1. The recent BCx bottle shortage necessitated enhanced BCx stewardship. At two hospitals during the shortage, SEP-1 metric compliance declined related to BCx utilization. Review of cases where BCx were not obtained demonstrated most BCx were safely avoided without demonstrable patient harm.

## Full-text entities

- **Genes:** SEPTIN1 (septin 1) [NCBI Gene 1731] {aka DIFF6, LARP, PNUTL3, SEP1, SEPT1, Septin-1}
- **Chemicals:** BCx (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12926338/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12926338/full.md

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Source: https://tomesphere.com/paper/PMC12926338