# Permanent Pacemaker Timing Dilemma in Recovered Lymphocytic Myocarditis

**Authors:** Keita Tashiro, Takeshi Kashimura, Ryohei Sakai, Takayuki Inomata

PMC · DOI: 10.1016/j.jaccas.2025.106239 · JACC Case Reports · 2025-12-02

## TL;DR

A patient with lymphocytic myocarditis showed full heart function recovery but persistent conduction issues, complicating pacemaker implantation timing.

## Contribution

Highlights the dissociation between systolic and conduction recovery in myocarditis, impacting pacemaker decisions.

## Key findings

- Cardiac function normalized, but complete atrioventricular block persisted despite recovery from myocarditis.
- Conventional indicators of recovery did not predict conduction system improvement.
- Permanent pacemaker was implanted despite normal cardiac enzymes and imaging.

## Abstract

The timing of permanent pacemaker implantation in myocarditis-related complete heart block remains challenging because no established criteria exist for reversibility of the conduction system.

A previously healthy 50-year-old Asian woman presented with lymphocytic myocarditis complicated by cardiogenic shock and complete atrioventricular block (CAVB). Despite successful hemodynamic stabilization with Impella CP support and complete recovery from left ventricular dysfunction, CAVB persisted. A permanent pacemaker was implanted on day 28. Afterward, cardiac enzymes and left ventricular function remained normal, and follow-up cardiac magnetic resonance showed no myocardial edema or late gadolinium enhancement. However, CAVB remained.

This case demonstrates dissociation between cardiac recovery of systolic function and conduction system recovery in myocarditis. Despite complete normalization of all conventional indicators, conduction impairment persisted, highlighting the complexity of permanent pacemaker timing decisions.

Cardiac functional recovery does not always correlate with conduction system recovery in myocarditis. Comprehensive evaluation is essential for permanent pacemaker timing decisions.

## Linked entities

- **Diseases:** cardiogenic shock (MONDO:0800175), complete atrioventricular block (MONDO:0000468)

## Full-text entities

- **Diseases:** Lymphocytic Myocarditis (MESH:D009205), left ventricular dysfunction (MESH:D018487), myocardial edema (MESH:D004487), heart block (MESH:D006327), CAVB (MESH:D054537), cardiogenic shock (MESH:D012770)
- **Chemicals:** gadolinium (MESH:D005682)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12926214/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12926214/full.md

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Source: https://tomesphere.com/paper/PMC12926214