# From microtubule remodeling to clinical translation: the multifaceted roles of vasohibin-1 in disease modulation

## TL;DR

Vasohibin-1 (VASH-1) is a protein involved in blood vessel regulation and has complex roles in diseases, making it a potential target for diagnosis and treatment.

## Contribution

This review systematically explores VASH-1's multi-dimensional roles, paradoxical functions, and translational potential across diseases.

## Key findings

- VASH-1 regulates vascular homeostasis through microtubule remodeling.
- It shows paradoxical expression in different cancers, inhibiting or promoting angiogenesis.
- VASH-1 serves as a diagnostic marker and therapeutic target in renal and cancer diseases.

## Abstract

Vasohibin-1 (VASH-1) is an endothelial protein that serves as a negative feedback regulator of angiogenesis. Through its microtubule carboxypeptidase activity, VASH-1 plays a key role in vascular homeostasis. While previous studies have investigated its involvement in vascular regulation, most have focused on isolated functions or specific disease models, without systematically addressing its multi-dimensional regulatory mechanisms, tissue-specific functional paradoxes, and translational potential. This review provides a comprehensive analysis of VASH-1’s biological characteristics: its expression is induced by pro-angiogenic factors, and it forms a functional complex with SVBP. In pathological contexts, VASH-1 exhibits paradoxical expression patterns—downregulated in neuroendocrine tumors but upregulated in bladder cancer—and demonstrates tissue-specific functions that either inhibit or promote angiogenesis. Clinically, VASH-1 serves both as a diagnostic marker (e.g., serum biomarker and tissue-based prognostic indicator) and a therapeutic target (such as improving renal disease or promoting tumor vascular normalization). This review aims to elucidate the complex physiological and pathological roles of VASH-1, providing a foundation for future precision intervention strategies targeting VASH-1 in disease diagnosis and therapy.

Diagram illustrating the roles of VASH-1 in disease modulation. Center features VASH-1 structure. Top left: Microtubule remodeling with α-tubulin detyrosination. Top right: Angiogenesis regulation with endothelial cells and vascular homeostasis. Bottom left: Disease modulation showing cancer, renal diseases, and autoimmune disorders. Bottom right: Clinical translation highlighting biomarkers and therapeutic targets.