# ST-Segment Elevation Myocardial Infarction From Carney Complex Familial Myxoma Embolization

**Authors:** Ahad Firoz, Spencer Kitchin, Alirameen Akram, Saul Schaefer

PMC · DOI: 10.1016/j.jaccas.2025.106120 · JACC Case Reports · 2025-11-19

## TL;DR

A young man with Carney complex developed a heart attack due to a myxoma embolism, requiring emergency treatment and surgery.

## Contribution

This case highlights the rare occurrence of STEMI from myxoma embolization in Carney complex and its management.

## Key findings

- STEMI in young CNC patients is often caused by cardiac myxoma embolization.
- Percutaneous coronary intervention with thrombectomy is a common acute treatment for this condition.
- Surgical myxoma excision is necessary for long-term management despite high recurrence rates.

## Abstract

Carney complex (CNC) is a rare condition associated with multiorgan system tumors. Cardiac myxomas are a frequent complication of this disease.

A 20-year old man with CNC presented with 3 days of dyspnea. Echocardiography revealed a rapidly growing left atrial myxoma. He developed chest pain (score: 10/10) during his hospitalization and was found to have an acute inferior ST-segment elevation myocardial infarction (STEMI). Emergent percutaneous balloon angioplasty and aspiration thrombectomy were performed, with eventual surgical myxoma excision.

STEMI due to myxoma embolization is rare and poorly understood. This case highlights the pathophysiology and complications associated with CNC, the acute therapeutic interventions for STEMI from myxoma embolization, and the long-term management of atrial myxomas.

In young patients with CNC, STEMI is often embolic from cardiac myxomas; acute treatment typically involves percutaneous coronary intervention with thrombectomy rather than stent placement. Definitive treatment involves surgical excision of the myxoma using a multidisciplinary approach, although recurrence rates are high in CNC.

## Linked entities

- **Diseases:** Carney complex (MONDO:0015285), ST-segment elevation myocardial infarction (MONDO:0041656), myxoma (MONDO:0044784)

## Full-text entities

- **Diseases:** ST-Segment Elevation Myocardial Infarction (MESH:D000072657), CNC (MESH:D056733), Cardiac myxomas (MESH:D009232), Familial Myxoma (MESH:C538262), chest pain (MESH:D002637), embolic (MESH:D004617), multiorgan system tumors (MESH:D009369), dyspnea (MESH:D004417)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12926079/full.md

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Source: https://tomesphere.com/paper/PMC12926079