# Isolated Congenital Hyponychia and Anonychia in a Neonate: A Rare Case

**Authors:** Sanjaykumar Tanti, Sandeep Jhajra, Veera Harshini, Anil Kumar

PMC · DOI: 10.7759/cureus.102176 · Cureus · 2026-01-23

## TL;DR

A full-term baby was born with rare nail abnormalities, including partial and complete absence of fingernails and toenails, with no other health issues.

## Contribution

This case report highlights the rare occurrence of isolated congenital hyponychia and anonychia in a neonate without associated syndromes.

## Key findings

- The neonate exhibited both hyponychia and anonychia affecting all fingernails and toenails.
- No systemic abnormalities or syndromic features were identified in the baby.
- The condition is likely isolated and carries a good prognosis when no other features are present.

## Abstract

Congenital hyponychia and anonychia are extremely rare nail disorders characterized by the partial or complete absence of nails. These conditions may be inherited or associated with in utero exposure to teratogenic substances. A full-term male neonate underwent routine head-to-toe examination in the labor room. The baby was noted to have both incomplete (hyponychia) and complete (anonychia) absence of fingernails and toenails. No other systemic abnormalities were identified. Isolated congenital hyponychia and anonychia are uncommon findings in neonates. In the absence of syndromic features, the condition generally carries an excellent prognosis.

## Linked entities

- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Genes:** RSPO4 (R-spondin 4) [NCBI Gene 343637] {aka C20orf182, CRISTIN4}
- **Diseases:** rashes (MESH:D005076), skeletal abnormalities (MESH:D009139), DOOR syndrome (MESH:C563052), mucosal lesions (MESH:D009059), alopecia (MESH:D000505), gestational diabetes (MESH:D016640), ectodermal dysplasia (MESH:D004476), hypoplastic (MESH:D000741), systemic abnormalities (MESH:D015619), cardiac defects (MESH:D006331), microcephaly (MESH:D008831), orofacial anomalies (MESH:D020820), absence (MESH:D004832), seizures (MESH:D012640), hypoplastic (underdeveloped (MESH:C000721289), developmental delay (MESH:D002658), onychodystrophy (OMIM:614149), congenital nail hypoplasia (MESH:C565591), nail-patella syndrome (MESH:D009261), polydactyly (MESH:D017689), Stevens-Johnson syndrome (MESH:D013262), bony defects (MESH:D018213), trauma (MESH:D014947), organomegaly (MESH:D016878), hypoplasia (MESH:D000080344), lichen planus (MESH:D008010), inflammation (MESH:D007249), Congenital nail anomalies (MESH:D009264), EEC syndrome (MESH:C536189), intellectual disability (MESH:D008607), epidermolysis bullosa (MESH:D004820), hereditary nail hypoplasia syndromes (MESH:D009386), brachydactyly (MESH:D059327), Nail hypoplasia (MESH:D009260), congenital nail hypoplasia or absence (MESH:D000757), isolated congenital nail hypoplasia (MESH:C538333), syndromes (MESH:D013577), deafness (MESH:D003638), aplasia (MESH:C536482), infections (MESH:D007239), osteodystrophy (MESH:D012080), dysmorphic (MESH:D057215), missing (MESH:D000030), Cook's syndrome (MESH:C537766), Congenital Hyponychia (MESH:C536377), Zimmermann-Laband syndrome (MESH:C536725), bullying (MESH:D000073397), hair abnormalities (MESH:D006201), craniofacial, skeletal, or other systemic anomalies (MESH:D019465), Ellis-van Creveld syndrome (MESH:D004613), anxiety (MESH:D001007)
- **Chemicals:** carbamazepine (MESH:D002220), trimethadione (MESH:D014293), warfarin (MESH:D014859), morphine (MESH:D009020), phenytoin (MESH:D010672)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12925987/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12925987/full.md

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Source: https://tomesphere.com/paper/PMC12925987