# Recurrent Rheumatic Carditis Presenting With Severe Biventricular Dysfunction Despite a Normally Functioning Mechanical Mitral Valve

**Authors:** José Victor da Nóbrega Borges, Samira Abdel Correia Leila

PMC · DOI: 10.1016/j.jaccas.2025.106068 · JACC Case Reports · 2025-11-20

## TL;DR

A man with a history of rheumatic heart disease developed severe heart dysfunction years after valve surgery, likely due to a rare recurrence of rheumatic carditis.

## Contribution

Highlights the rare recurrence of rheumatic carditis in adults post-valve surgery and its potential to cause biventricular dysfunction.

## Key findings

- A 44-year-old man with a mechanical mitral valve showed severe biventricular dysfunction despite normal valve function.
- Recurrent rheumatic carditis was suspected based on elevated inflammatory markers and clinical response to anti-inflammatory therapy.

## Abstract

Rheumatic heart disease (RHD) remains a major cause of cardiovascular morbidity in endemic regions. Recurrence of acute rheumatic fever (ARF) in adults, especially after valve surgery, is rare but clinically significant.

A 44-year-old man with rheumatic mitral stenosis underwent mechanical mitral valve replacement. He presented 5 years later with dyspnea, orthopnea, and fatigue. Echocardiography showed new severe biventricular systolic dysfunction (left ventricular ejection fraction 20%) with preserved prosthetic function. Coronary computed tomography angiography excluded obstructive disease, and pulmonary embolism was ruled out. Elevated inflammatory markers raised suspicion for recurrent rheumatic carditis. He received anti-inflammatory therapy and guideline-directed medical therapy for heart failure, with progressive recovery.

Recurrent ARF should remain a diagnostic consideration in adults with prior RHD and new ventricular dysfunction, even after valve replacement.

Recurrent ARF may occur post-surgery and cause myocardial dysfunction. Echocardiography and multimodality imaging are essential for diagnosis and management.

## Linked entities

- **Diseases:** rheumatic heart disease (MONDO:0006955), acute rheumatic fever (MONDO:0017767)

## Full-text entities

- **Diseases:** fatigue (MESH:D005221), myocardial dysfunction (MESH:D006331), rheumatic mitral stenosis (MESH:D008946), dyspnea (MESH:D004417), heart failure (MESH:D006333), ARF (MESH:D012213), pulmonary embolism (MESH:D011655), obstructive disease (MESH:D001157), Biventricular Dysfunction (MESH:D018754), Rheumatic Carditis (MESH:D009205), RHD (MESH:D012214), biventricular systolic dysfunction (MESH:D018487), inflammatory (MESH:D007249)

## Full text

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## Figures

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12925962/full.md

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Source: https://tomesphere.com/paper/PMC12925962