# Transitioning from human primordial germ cells to embryonic germ cells

## TL;DR

Scientists derived human embryonic germ cells from primordial germ cells and studied their genetic and epigenetic changes.

## Contribution

The study successfully derived human EGC-like cells and analyzed their multi-omic profiles for the first time.

## Key findings

- Human EGC-like cells were derived from PGC-like cells.
- Multi-omic profiling revealed insights into pluripotency and epigenetic dynamics.
- Findings provide new understanding of human germ cell tumorigenesis mechanisms.

## Abstract

Primordial germ cells (PGCs) can give rise to pluripotent embryonic germ cells (EGCs) in rodents. Leitch and colleagues in this issue successfully derived human EGC-like cells from PGC-like cells and applied comprehensive multi-omic profiling to resolve their pluripotent and epigenetic dynamics, providing new insights into potential mechanisms underlying human germ cell tumorigenesis.

Primordial germ cells (PGCs) can give rise to pluripotent embryonic germ cells (EGCs) in rodents. Stucchi et al. in this issue successfully derived human EGC-like cells from PGC-like cells and applied comprehensive multi-omic profiling to resolve their pluripotent and epigenetic dynamics, providing new insights into potential mechanisms underlying human germ cell tumorigenesis.