# N6-methyladenosine methylation in acute lung injury: Mechanisms and research progress

## TL;DR

This paper reviews how N6-methyladenosine RNA modification influences acute lung injury and explores its potential for new treatments.

## Contribution

The paper provides an updated review of m6A methylation's role in ALI and its regulatory mechanisms.

## Key findings

- Aberrant m6A regulators are linked to ALI development.
- M6A writers, erasers, and readers play key roles in ALI molecular mechanisms.
- Understanding m6A could lead to new therapeutic strategies for ALI.

## Abstract

N6-methyladenosine (m6A) methylation is the most prevalent and abundant internal post-transcriptional RNA modification in eukaryotic cells, playing an important regulatory role in various biological processes. The biological functions of m6A modification are dynamically and reversibly mediated by methyltransferases (writers), demethylases (erasers), and m6A binding proteins (readers). Acute lung injury (ALI) is a common critical condition characterized by diffuse edema within the pulmonary interstitium and alveoli, and is associated with high morbidity and mortality. Recent studies have identified that aberrant expression of m6A regulators is closely associated with ALI development. This review highlights the progress in research on m6A writers, erasers, and readers in ALI, focusing on their molecular regulatory mechanisms. Elucidating the molecular mechanisms of m6A and its associated proteins in ALI may reveal new therapeutic strategies and targets.